The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application

The Wnt/β signaling pathway (Wnt-SP) is a phylogenetically ancient mechanism that regulates development and maintains tissue homeostasis through the control of cell proliferation, differentiation, migration, and apoptosis.

The accurate regulation of the canonical Wnt/β-catenin signaling pathway (Wnt-SP) is critical for embryogenesis and postnatal development; and impaired signaltransduction at one of its stages leads to various diseases, including organ malformations, cancers, metabolic and neurodegenerative disorders. The literature review discusses the biological role of the canonical Wnt-SP in the development of the skeleton and in the remodeling of bone tissue.

The Wnt signal transmission changes observed during genetic mutations cause various human skeletal diseases.

CKMM antibody

10C-CR3014M2 1 mg
EUR 379
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10C-CR3014M3 1 mg
EUR 495
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10R-8516 100 ul
EUR 393
Description: Mouse monoclonal CKMM antibody

CKMM antibody

20-CG75 1 ml
EUR 173
Description: Goat polyclonal CKMM antibody

CKMM antibody

20-CR75 1 ml
EUR 173
Description: Rabbit polyclonal CKMM antibody

CKMM antibody

20C-CR3014G 1 ml
EUR 225
Description: Goat polyclonal CKMM antibody

CKMM antibody

70-XG47 1 mg
EUR 324
Description: Affinity purified Goat polyclonal CKMM antibody

CKMM antibody

70R-1984 50 ug
EUR 467
Description: Rabbit polyclonal CKMM antibody raised against the N terminal of CKM

CKMM antibody

70R-1985 50 ug
EUR 467
Description: Rabbit polyclonal CKMM antibody raised against the middle region of CKM

CKMM protein

30-1083 1000 units
EUR 791
Description: Purified native Human CKMM protein

CKMM protein

30-1084U 100 units
EUR 279
Description: Highly pure native Human CKMM protein

CKMM protein

30-1369 500 ug
EUR 392
Description: Recombinant CKMM protein

CKMM protein

30-AC60 1 mg
EUR 398
Description: Purified native Human CKMM protein

CKMM protein

30-AC61 100 ug
EUR 271
Description: Purified recombinant CKMM protein

CKMM protein

30R-3024 200 ug
EUR 354
Description: Purified recombinant CKMM protein

CKMM antibody

70R-33149 100 ug
EUR 435
Description: Rabbit polyclonal CKMM antibody

CKMM antibody

70R-15270 100 ug
EUR 327
Description: Rabbit polyclonal CKMM antibody

7095B 9 PASTEUR PIPET

7095B-9 200/pk
EUR 70
Description: Disposable Pipets; Pasteur Pipets

Individual Reaction Mix 9

G065-9 200 reactions
EUR 167

Mouse CKMM Antibody

32938-05111 150 ug
EUR 261

Rat CKMM Antibody

32939-05111 150 ug
EUR 261

anti-CKMM (3C3)

LF-MA0399 100 ul
EUR 334
Description: Mouse monoclonal to CKMM

anti-CKMM (11B11)

LF-MA0400 100 ul
EUR 334
Description: Mouse monoclonal to CKMM

CKMM Blocking Peptide

33R-3630 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1985

CKMM antibody (HRP)

60R-1648 100 ug
EUR 327
Description: Rabbit polyclonal CKMM antibody (HRP)

CKMM antibody (FITC)

60R-1649 100 ug
EUR 327
Description: Rabbit polyclonal CKMM antibody (FITC)

CKMM antibody (biotin)

60R-1650 100 ug
EUR 349
Description: Rabbit polyclonal CKMM antibody (biotin)

CKMM Blocking Peptide

33R-9549 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1984

7095D 9 PASTEUR PIPET BOROSILICATE

7095D-9 200/pk
EUR 78
Description: Disposable Pipets; Pasteur Pipets

CKMM Type 1 protein

30R-AC026 1 mg
EUR 791
Description: Purified recombinant CKMM Type 1 protein

Human Brain Tissue Preparation Buffer 9: Normal Nerve Microglia

9-80021 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 9: Kidney Tumor Cells

9-80032 1 x 100 ml Ask for price

Mouse Brain Tissue Preparation Buffer 9: Normal Nerve Microglia

9-80132 1 x 100 ml Ask for price

Rat Brain Tissue Preparation Buffer 9: Normal Neuron Cells

9-80227 1 x 100 ml Ask for price

Mouse CKMM Antibody (Biotin Conjugate)

32938-05121 150 ug
EUR 369

Rat CKMM Antibody (Biotin Conjugate)

32939-05121 150 ug
EUR 369

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RD-Ang1-9-Hu-48Tests 48 Tests
EUR 503

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RD-Ang1-9-Hu-96Tests 96 Tests
EUR 697

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DLR-Ang1-9-Hu-48T 48T
EUR 501
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Angiotensin 1-9 (Ang1-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DLR-Ang1-9-Hu-96T 96T
EUR 651
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Angiotensin 1-9 (Ang1-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RDR-Ang1-9-Hu-48Tests 48 Tests
EUR 525

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RDR-Ang1-9-Hu-96Tests 96 Tests
EUR 729

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RD-CA19-9-Hu-48Tests 48 Tests
EUR 436

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RD-CA19-9-Hu-96Tests 96 Tests
EUR 601

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DLR-CA19-9-Hu-48T 48T
EUR 441
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-9 (CA19-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DLR-CA19-9-Hu-96T 96T
EUR 570
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-9 (CA19-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RDR-CA19-9-Hu-48Tests 48 Tests
EUR 455

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RDR-CA19-9-Hu-96Tests 96 Tests
EUR 629

Mouse CKMM AssayLite Antibody (FITC Conjugate)

32938-05141 150 ug
EUR 428

Mouse CKMM AssayLite Antibody (RPE Conjugate)

32938-05151 150 ug
EUR 428

Mouse CKMM AssayLite Antibody (APC Conjugate)

32938-05161 150 ug
EUR 428

Mouse CKMM AssayLite Antibody (PerCP Conjugate)

32938-05171 150 ug
EUR 471

Rat CKMM AssayLite Antibody (FITC Conjugate)

32939-05141 150 ug
EUR 428

Rat CKMM AssayLite Antibody (RPE Coinjugate)

32939-05151 150 ug
EUR 428

Rat CKMM AssayLite Antibody (APC Conjugate)

32939-05161 150 ug
EUR 428

Rat CKMM AssayLite Antibody (PerCP Conjugate)

32939-05171 150 ug
EUR 471

Human Creatine Kinase M-type (CKMM) Antibody

11281-05011 150 ug
EUR 217

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-10ug 10ug
EUR 141
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-1mg 1mg
EUR 1674
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-500ug 500ug
EUR 1186
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-50ug 50ug
EUR 263
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Mouse pre-microRNA Expression Construct mir-9-1

MMIR-9-1-PA-1 Bacterial Streak
EUR 684

Mouse pre-microRNA Expression Construct mir-9-2

MMIR-9-2-PA-1 Bacterial Streak
EUR 684

Mouse pre-microRNA Expression Construct mir-9-3

MMIR-9-3-PA-1 Bacterial Streak
EUR 684

CEA (Cancer antigen) ELISA test

9 96T/Box Ask for price
Description: ELISA based test for quantitative detection of CEA (Cancer antigen)

Human Creatine Kinase M-type (CKMM) Antibody (Biotin Conjugate)

11281-05021 150 ug
EUR 276

AQP1-AQP9 and AQPAP control/blocking peptides (25 ug each of AQP1-9)

AQP0-9-AP-P 25 ug x10
EUR 986

Rabbit Anti-AQP1-AQP9 and AQPAP Antiserum (25 ul each of AQP1-9)

AQP0-9-AP-S 25 ul x10
EUR 1085

Rabbit Anti-AQP1-AQP9 and AQPAP, aff. pure (25 ug each of AQP1-9)

AQP0-9-AP-A 25 ul x10
EUR 1207

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (FITC Conjugate)

11281-05041 150 ug
EUR 428

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (RPE Conjugate)

11281-05051 150 ug
EUR 428

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (APC Conjugate)

11281-05061 150 ug
EUR 428

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (PerCP Conjugate)

11281-05071 150 ug
EUR 471

IL-9, Interleukin-9, human

RC212-20 10ug
EUR 169.63

Matrix Metalloproteinase 9 (MMP-9)

GT15020 100 ug
EUR 526

Frizzled 9 (Frizzled 9) Antibody

20-abx121993
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Calpain 9 (Calpain 9) Antibody

20-abx111332
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Frizzled 9 (Frizzled 9) Antibody

20-abx008534
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Frizzled 9 (Frizzled 9) Antibody

abx233223-100ug 100 ug
EUR 481

Calpain 9 (Calpain 9) Antibody

abx231218-100ug 100 ug
EUR 481

Human Keratin- associated protein 9- 9, KRTAP9-9 ELISA KIT

ELI-38944h 96 Tests
EUR 824

Mouse Galectin-9 (Gal-9) Antibody

32253-05111 150 ug
EUR 261

Human Interleukin-9 (IL-9) Antibody

32578-05111 150 ug
EUR 261

Angiotensin 1-9 (Ang1-9) Antibody

20-abx132109
  • EUR 342.00
  • EUR 885.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Matrix Metalloproteinase 9 (MMP-9) Antibody

abx414532-02mg 0.2 mg
EUR 634

Matrix Metalloproteinase 9 (MMP-9) Antibody

abx414533-01mg 0.1 mg
EUR 439

Human 19-9(CA19-9)ELISA

QY-E05335 96T
EUR 374

Rat Angiotensin 1-9(Ang1-9)

QY-E11784 96T
EUR 374

AA26-9

HY-18522 50mg
EUR 2116

C188-9

HY-112288 10mM/1mL
EUR 176

ISX-9

HY-12323 100mg
EUR 670

9-Propenyladenine

HY-100079 100mg
EUR 2943

9-Methoxycamptothecin

HY-N6011 5mg
EUR 119

(Arg)9

HY-P0133 1mg
EUR 215

9-Aminoacridine

HY-B1422 10mM/1mL
EUR 126

FGF-9

PR27017 20 ug
EUR 318

Understanding the functional mechanism involved in the development of bone abnormality could open new horizons in the treatment of osteoporosis, by affecting the Wnt-SP. The design of antibodies to sclerostin, a Wnt-SP inhibitor, is most promising now. The paper summarizes the studies that have investigated the canonical Wnt-SP and designed drugs to treat osteoporosis.