The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application

The Wnt/β signaling pathway (Wnt-SP) is a phylogenetically ancient mechanism that regulates development and maintains tissue homeostasis through the control of cell proliferation, differentiation, migration, and apoptosis.

The accurate regulation of the canonical Wnt/β-catenin signaling pathway (Wnt-SP) is critical for embryogenesis and postnatal development; and impaired signaltransduction at one of its stages leads to various diseases, including organ malformations, cancers, metabolic and neurodegenerative disorders. The literature review discusses the biological role of the canonical Wnt-SP in the development of the skeleton and in the remodeling of bone tissue.

The Wnt signal transmission changes observed during genetic mutations cause various human skeletal diseases.

CKMM antibody

10C-CR3014M1 1 mg
EUR 495.00
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10C-CR3014M2 1 mg
EUR 379.00
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10C-CR3014M3 1 mg
EUR 495.00
Description: Mouse monoclonal CKMM antibody

CKMM antibody

70R-1984 50 ug
EUR 467.00
Description: Rabbit polyclonal CKMM antibody raised against the N terminal of CKM

CKMM antibody

70R-1985 50 ug
EUR 467.00
Description: Rabbit polyclonal CKMM antibody raised against the middle region of CKM

CKMM antibody

70R-33149 100 ug
EUR 435.00
Description: Rabbit polyclonal CKMM antibody

CKMM protein

30R-3024 200 ug
EUR 354.00
Description: Purified recombinant CKMM protein

CKMM protein

30-1083 1000 units
EUR 791.00
Description: Purified native Human CKMM protein

CKMM protein

30-1084U 100 units
EUR 279.00
Description: Highly pure native Human CKMM protein

CKMM protein

30-1369 500 ug
EUR 392.00
Description: Recombinant CKMM protein

CKMM protein

30-AC60 1 mg
EUR 398.00
Description: Purified native Human CKMM protein

CKMM protein

30-AC61 100 ug
EUR 271.00
Description: Purified recombinant CKMM protein

CKMM antibody

10R-8516 100 ul
EUR 393.00
Description: Mouse monoclonal CKMM antibody

CKMM antibody

20C-CR3014G 1 ml
EUR 225.00
Description: Goat polyclonal CKMM antibody

CKMM antibody

20-CG75 1 ml
EUR 173.00
Description: Goat polyclonal CKMM antibody

CKMM antibody

20-CR75 1 ml
EUR 173.00
Description: Rabbit polyclonal CKMM antibody

CKMM antibody

70-XG47 1 mg
EUR 324.00
Description: Affinity purified Goat polyclonal CKMM antibody

CKMM antibody

70R-15270 100 ug
EUR 327.00
Description: Rabbit polyclonal CKMM antibody

CKMM, Human

LF-P0096 0.2 mg
EUR 303.00
Description: CKMM, Human protein

CKMM Blocking Peptide

33R-3630 100 ug
EUR 180.00
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1985

CKMM Blocking Peptide

33R-9549 100 ug
EUR 180.00
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1984

CKMM antibody (HRP)

60R-1648 100 ug
EUR 327.00
Description: Rabbit polyclonal CKMM antibody (HRP)

CKMM antibody (FITC)

60R-1649 100 ug
EUR 327.00
Description: Rabbit polyclonal CKMM antibody (FITC)

CKMM antibody (biotin)

60R-1650 100 ug
EUR 349.00
Description: Rabbit polyclonal CKMM antibody (biotin)

anti-CKMM (3C3)

LF-MA0399 100 ul
EUR 334.00
Description: Mouse monoclonal to CKMM

anti-CKMM (11B11)

LF-MA0400 100 ul
EUR 334.00
Description: Mouse monoclonal to CKMM

Mouse CKMM Antibody

32938-05111 150 ug
EUR 261.00

Rat CKMM Antibody

32939-05111 150 ug
EUR 261.00

7095B 9 PASTEUR PIPET

7095B-9 200/pk
EUR 70.00
Description: Disposable Pipets; Pasteur Pipets

Individual Reaction Mix 9

G065-9 200 reactions
EUR 167.00

7095D 9 PASTEUR PIPET BOROSILICATE

7095D-9 200/pk
EUR 78.00
Description: Disposable Pipets; Pasteur Pipets

CKMM Type 1 protein

30R-AC026 1 mg
EUR 791.00
Description: Purified recombinant CKMM Type 1 protein

Human ckmm PicoKine ELISA Kit

EK1751 96 wells
EUR 425.00
Description: For quantitative detection of human ckmm in cell culture supernates, serum and plasma (heparin, EDTA).

Mouse CKMM Antibody (Biotin Conjugate)

32938-05121 150 ug
EUR 369.00

Rat CKMM Antibody (Biotin Conjugate)

32939-05121 150 ug
EUR 369.00

Human Brain Tissue Preparation Buffer 9: Normal Nerve Microglia

9-80021 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 9: Kidney Tumor Cells

9-80032 1 x 100 ml Ask for price

Mouse Brain Tissue Preparation Buffer 9: Normal Nerve Microglia

9-80132 1 x 100 ml Ask for price

Rat Brain Tissue Preparation Buffer 9: Normal Neuron Cells

9-80227 1 x 100 ml Ask for price

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DL-Ang1-9-Hu-192 1 kit of 192 tests
EUR 1110.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of Human Angiotensin 1-9 (Ang1-9)

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DL-Ang1-9-Hu-48 1 kit of 48 tests
EUR 467.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of Human Angiotensin 1-9 (Ang1-9)

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DL-Ang1-9-Hu-96 1 kit of 96 tests
EUR 625.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of Human Angiotensin 1-9 (Ang1-9)

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DLR-Ang1-9-Hu-48T 48T
EUR 501.00
  • Should the Human Angiotensin 1-9 (Ang1-9) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Angiotensin 1-9 (Ang1-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DLR-Ang1-9-Hu-96T 96T
EUR 651.00
  • Should the Human Angiotensin 1-9 (Ang1-9) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Angiotensin 1-9 (Ang1-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RD-Ang1-9-Hu-48Tests 48 Tests
EUR 503.00

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RD-Ang1-9-Hu-96Tests 96 Tests
EUR 697.00

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RDR-Ang1-9-Hu-48Tests 48 Tests
EUR 525.00

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RDR-Ang1-9-Hu-96Tests 96 Tests
EUR 729.00

Mouse CKMM AssayLite Antibody (FITC Conjugate)

32938-05141 150 ug
EUR 428.00

Mouse CKMM AssayLite Antibody (RPE Conjugate)

32938-05151 150 ug
EUR 428.00

Mouse CKMM AssayLite Antibody (APC Conjugate)

32938-05161 150 ug
EUR 428.00

Mouse CKMM AssayLite Antibody (PerCP Conjugate)

32938-05171 150 ug
EUR 471.00

Rat CKMM AssayLite Antibody (FITC Conjugate)

32939-05141 150 ug
EUR 428.00

Rat CKMM AssayLite Antibody (RPE Coinjugate)

32939-05151 150 ug
EUR 428.00

Rat CKMM AssayLite Antibody (APC Conjugate)

32939-05161 150 ug
EUR 428.00

Rat CKMM AssayLite Antibody (PerCP Conjugate)

32939-05171 150 ug
EUR 471.00

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DL-CA19-9-Hu-192 1 kit of 192 tests
EUR 955.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Carbohydrate Antigen 19-9 (CA19-9)

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DL-CA19-9-Hu-48 1 kit of 48 tests
EUR 413.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Carbohydrate Antigen 19-9 (CA19-9)

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DL-CA19-9-Hu-96 1 kit of 96 tests
EUR 547.00
Description: An ELISA kit based on the sandwich method for detection and quantification of Human Carbohydrate Antigen 19-9 (CA19-9)

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DLR-CA19-9-Hu-48T 48T
EUR 441.00
  • Should the Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-9 (CA19-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DLR-CA19-9-Hu-96T 96T
EUR 570.00
  • Should the Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-9 (CA19-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RD-CA19-9-Hu-48Tests 48 Tests
EUR 436.00

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RD-CA19-9-Hu-96Tests 96 Tests
EUR 601.00

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RDR-CA19-9-Hu-48Tests 48 Tests
EUR 455.00

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RDR-CA19-9-Hu-96Tests 96 Tests
EUR 629.00

Human Creatine Kinase M-type (CKMM) Antibody

11281-05011 150 ug
EUR 217.00

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-10ug 10ug
EUR 141.00
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-1mg 1mg
EUR 1674.00
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-500ug 500ug
EUR 1186.00
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-50ug 50ug
EUR 263.00
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Human Creatine Kinase M-type (CKMM) Antibody (Biotin Conjugate)

11281-05021 150 ug
EUR 276.00

Mouse pre-microRNA Expression Construct mir-9-1

MMIR-9-1-PA-1 Bacterial Streak
EUR 684.00
  • Category: MicroRNA Tools

Mouse pre-microRNA Expression Construct mir-9-2

MMIR-9-2-PA-1 Bacterial Streak
EUR 684.00
  • Category: MicroRNA Tools

Mouse pre-microRNA Expression Construct mir-9-3

MMIR-9-3-PA-1 Bacterial Streak
EUR 684.00
  • Category: MicroRNA Tools

CEA (Cancer antigen) ELISA test

9 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of CEA (Cancer antigen)

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (FITC Conjugate)

11281-05041 150 ug
EUR 428.00

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (RPE Conjugate)

11281-05051 150 ug
EUR 428.00

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (APC Conjugate)

11281-05061 150 ug
EUR 428.00

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (PerCP Conjugate)

11281-05071 150 ug
EUR 471.00

AQP1-AQP9 and AQPAP control/blocking peptides (25 ug each of AQP1-9)

AQP0-9-AP-P 25 ug x10
EUR 986.00

Rabbit Anti-AQP1-AQP9 and AQPAP Antiserum (25 ul each of AQP1-9)

AQP0-9-AP-S 25 ul x10
EUR 1085.00

Rabbit Anti-AQP1-AQP9 and AQPAP, aff. pure (25 ug each of AQP1-9)

AQP0-9-AP-A 25 ul x10
EUR 1207.00

Frizzled 9 (Frizzled 9) Antibody

20-abx008534
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Calpain 9 (Calpain 9) Antibody

20-abx111332
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Frizzled 9 (Frizzled 9) Antibody

20-abx121993
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Calpain 9 (Calpain 9) Antibody

abx231218-100ug 100 ug
EUR 481.00
  • Shipped within 5-12 working days.

Frizzled 9 (Frizzled 9) Antibody

abx233223-100ug 100 ug
EUR 481.00
  • Shipped within 5-12 working days.

IL-9, Interleukin-9, human

RC212-20 10ug
EUR 169.63
  • Product category: Proteins/Recombinant Proteins/Cytokines

Matrix Metalloproteinase 9 (MMP-9)

GT15020 100 ug
EUR 526.00

Human Keratin- associated protein 9- 9, KRTAP9-9 ELISA KIT

ELI-38944h 96 Tests
EUR 824.00

Angiotensin 1-9 (Ang1-9) Antibody

20-abx132109
  • EUR 342.00
  • EUR 885.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Matrix Metalloproteinase 9 (MMP-9) Antibody

abx414532-02mg 0.2 mg
EUR 634.00
  • Shipped within 1 week.

Matrix Metalloproteinase 9 (MMP-9) Antibody

abx414533-01mg 0.1 mg
EUR 439.00
  • Shipped within 1 week.

Mouse Galectin-9 (Gal-9) Antibody

32253-05111 150 ug
EUR 261.00

Human Interleukin-9 (IL-9) Antibody

32578-05111 150 ug
EUR 261.00

Human 19-9(CA19-9)ELISA

QY-E05335 96T
EUR 374.00

Rat Angiotensin 1-9(Ang1-9)

QY-E11784 96T
EUR 374.00

Tyrphostin 9

B1494-25 25 mg
EUR 108.00
Description: Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5?M [1].Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991.

Tyrphostin 9

B1494-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5?M [1].Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991.

Tyrphostin 9

B1494-50 50 mg
EUR 119.00
Description: Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5?M [1].Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991.

9-Methylacridine

20-abx182360
  • EUR 300.00
  • EUR 704.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

9-Aminophenanthrene

20-abx186362
  • EUR 1205.00
  • EUR 3293.00
  • 1 g
  • 5 g
  • Shipped within 1-2 weeks.

9-Anthracenemethanol

20-abx186657
  • EUR 258.00
  • EUR 718.00
  • EUR 189.00
  • EUR 495.00
  • 100 g
  • 1 kg
  • 25 g
  • 500 g
  • Shipped within 1-2 weeks.

9-Anthraldehyde

20-abx186669
  • EUR 258.00
  • EUR 801.00
  • EUR 203.00
  • EUR 495.00
  • 100 g
  • 1 kg
  • 25 g
  • 500 g
  • Shipped within 1-2 weeks.

Cyclapolin 9

B7279-10 10 mg
EUR 284.00

Cyclapolin 9

B7279-50 50 mg
EUR 1038.00

RF 9

B7463-1 1 mg
EUR 212.00
Description: Ki: 58 nM for NPFF1; 75 nM for NPFF2RF 9 is a neuropeptide FF receptors antagonist.

RF 9

B7463-5 5 mg
EUR 393.00
Description: Ki: 58 nM for NPFF1; 75 nM for NPFF2RF 9 is a neuropeptide FF receptors antagonist.

RF 9

B7463-5.1 10 mM (in 1mL DMSO)
EUR 415.00
Description: Ki: 58 nM for NPFF1; 75 nM for NPFF2RF 9 is a neuropeptide FF receptors antagonist.

9-Phenanthrol

B7728-50 50 mg
EUR 125.00

ISX 9

B5596-10 10 mg
EUR 251.00

ISX 9

B5596-50 50 mg
EUR 902.00

SC-9

B6302-10 10 mg
EUR 284.00

9-AC

B6525-100 100 mg
EUR 145.00

AA26-9

B2159-5
EUR 207.00

9-Methoxycamptothecin

N2593-20 20 mg
EUR 398.00
Description: Extracted from Camptotheca acuminata in South, southwest China;Store the product in sealed, cool and dry condition

MEGA-9

P-1165.0001 1.0g
EUR 115.00
Description: Sum Formula: C16H33NO6; CAS# [85261-19-4]

MEGA-9

P-1165.0005 5.0g
EUR 368.00
Description: Sum Formula: C16H33NO6; CAS# [85261-19-4]

MEGA-9

P-1165.0025 25.0g
EUR 1385.00
Description: Sum Formula: C16H33NO6; CAS# [85261-19-4]

9-Nitrocamptothecin

TBW00049 20mg
EUR 307.00

9-Oxoageraphorone

TB01546 5mg
EUR 1016.00

9-Hydroxycalabaxanthone

TB01854 5mg
EUR 953.00

9-Methoxychrysophanol

TBW00467 20mg
EUR 697.00

9-Methymyrrhone

TBW01093 10mg Ask for price

9-Aminocamptothecin

TBZ2467 20mg Ask for price

9-Oxopodopyrone

TBZ0696 unit Ask for price

C188-9

HY-112288 10mM/1mL
EUR 176.00

9-Propenyladenine

HY-100079 100mg
EUR 2943.00

ISX-9

HY-12323 100mg
EUR 670.00

9-Methoxycamptothecin

HY-N6011 5mg
EUR 119.00

(Arg)9

HY-P0133 1mg
EUR 215.00

AA26-9

HY-18522 50mg
EUR 2116.00

9-Aminoacridine

HY-B1422 10mM/1mL
EUR 126.00

Caspase-9

GT15045 100 ul
EUR 500.00

GDF-9

GT15214 100 ug
EUR 526.00

FGF-9

GT15228 100 ug
EUR 526.00

9-Anthryldiazomethane

GT9079-100MG 100 mg
EUR 748.00

9-Chloromethylanthracene

GK9920-10G 10 g
EUR 146.00

9-Chloromethylanthracene

GK9920-25G 25 g
EUR 269.00

9-Chloromethylanthracene

GK9920-5G 5 g
EUR 94.00

Understanding the functional mechanism involved in the development of bone abnormality could open new horizons in the treatment of osteoporosis, by affecting the Wnt-SP. The design of antibodies to sclerostin, a Wnt-SP inhibitor, is most promising now. The paper summarizes the studies that have investigated the canonical Wnt-SP and designed drugs to treat osteoporosis.