The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application

The Wnt/β signaling pathway (Wnt-SP) is a phylogenetically ancient mechanism that regulates development and maintains tissue homeostasis through the control of cell proliferation, differentiation, migration, and apoptosis.

The accurate regulation of the canonical Wnt/β-catenin signaling pathway (Wnt-SP) is critical for embryogenesis and postnatal development; and impaired signaltransduction at one of its stages leads to various diseases, including organ malformations, cancers, metabolic and neurodegenerative disorders. The literature review discusses the biological role of the canonical Wnt-SP in the development of the skeleton and in the remodeling of bone tissue.

The Wnt signal transmission changes observed during genetic mutations cause various human skeletal diseases.

CKMM protein

30-AC61 100 ug
EUR 325.2
Description: Purified recombinant CKMM protein

CKMM protein

30-1083 1000 units
EUR 949.2
Description: Purified native Human CKMM protein

CKMM protein

30-1084U 100 units
EUR 334.8
Description: Highly pure native Human CKMM protein

CKMM antibody

10-C41A 1 mg
EUR 594
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10-C41B 1 mg
EUR 454.8
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10C-CR3014M1 1 mg
EUR 594
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10C-CR3014M2 1 mg
EUR 454.8
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10C-CR3014M3 1 mg
EUR 594
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10R-8516 100 ul
EUR 471.6
Description: Mouse monoclonal CKMM antibody

CKMM antibody

20C-CR3014G 1 ml
EUR 270
Description: Goat polyclonal CKMM antibody

CKMM antibody

20-CG75 1 ml
EUR 207.6
Description: Goat polyclonal CKMM antibody

CKMM antibody

20-CR75 1 ml
EUR 207.6
Description: Rabbit polyclonal CKMM antibody

CKMM antibody

70-XG47 1 mg
EUR 388.8
Description: Affinity purified Goat polyclonal CKMM antibody

CKMM antibody

70R-15270 100 ug
EUR 392.4
Description: Rabbit polyclonal CKMM antibody

CKMM antibody

70R-33149 100 ug
EUR 522
Description: Rabbit polyclonal CKMM antibody

CKMM antibody

70R-1984 50 ug
EUR 560.4
Description: Rabbit polyclonal CKMM antibody raised against the N terminal of CKM

CKMM antibody

70R-1985 50 ug
EUR 560.4
Description: Rabbit polyclonal CKMM antibody raised against the middle region of CKM

CKMM antibody

20R-CK004 1 L Ask for price
Description: Goat polyclonal CKMM antiserum

CKMM antibody

70R-CG004 1 G Ask for price
Description: Affinity purified Goat polyclonal CKMM antibody

CKMM antibody (HRP)

60R-1648 100 ug
EUR 392.4
Description: Rabbit polyclonal CKMM antibody (HRP)

Rat CKMM Antibody

32939-05111 150 ug
EUR 313.2

CKMM antibody (FITC)

60R-1649 100 ug
EUR 392.4
Description: Rabbit polyclonal CKMM antibody (FITC)

Mouse CKMM Antibody

32938-05111 150 ug
EUR 313.2

CKMM antibody (biotin)

60R-1650 100 ug
EUR 418.8
Description: Rabbit polyclonal CKMM antibody (biotin)

CKMM Blocking Peptide

33R-9549 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1984

CKMM Blocking Peptide

33R-3630 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1985

CKMM Type 1 protein

30R-AC026 1 mg
EUR 949.2
Description: Purified recombinant CKMM Type 1 protein

Human ckmm PicoKine ELISA Kit

EK1751 96 wells
EUR 510
Description: For quantitative detection of human ckmm in cell culture supernates, serum and plasma (heparin, EDTA).

Rat CKMM Antibody (Biotin Conjugate)

32939-05121 150 ug
EUR 442.8

Mouse CKMM Antibody (Biotin Conjugate)

32938-05121 150 ug
EUR 442.8

Rat CKMM AssayLite Antibody (APC Conjugate)

32939-05161 150 ug
EUR 513.6

Rat CKMM AssayLite Antibody (FITC Conjugate)

32939-05141 150 ug
EUR 513.6

Rat CKMM AssayLite Antibody (RPE Coinjugate)

32939-05151 150 ug
EUR 513.6

Mouse CKMM AssayLite Antibody (RPE Conjugate)

32938-05151 150 ug
EUR 513.6

Mouse CKMM AssayLite Antibody (APC Conjugate)

32938-05161 150 ug
EUR 513.6

Rat CKMM AssayLite Antibody (PerCP Conjugate)

32939-05171 150 ug
EUR 565.2

Mouse CKMM AssayLite Antibody (FITC Conjugate)

32938-05141 150 ug
EUR 513.6

Recombinant Human CKMM/CKM Protein, His Tag

E40KMH880 20ug
EUR 495

Mouse CKMM AssayLite Antibody (PerCP Conjugate)

32938-05171 150 ug
EUR 565.2

Human Creatine Kinase, Muscle(CKMM) Elisa Kit

EK700626 96 Wells
EUR 0.5

Human Creatine Kinase M-type (CKMM) Antibody

11281-05011 150 ug
EUR 260.4

Recombinant Human Creatine Kinase MM/CKMM Protein

RP02817LQ 50μg
EUR 58.5

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-10ug 10ug
EUR 169.2
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-1mg 1mg
EUR 2008.8
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-500ug 500ug
EUR 1423.2
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-50ug 50ug
EUR 315.6
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

AP75592 1mg
EUR 2369

Human Creatine Kinase M-type (CKMM) Antibody (Biotin Conjugate)

11281-05021 150 ug
EUR 331.2

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (RPE Conjugate)

11281-05051 150 ug
EUR 513.6

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (APC Conjugate)

11281-05061 150 ug
EUR 513.6

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (FITC Conjugate)

11281-05041 150 ug
EUR 513.6

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (PerCP Conjugate)

11281-05071 150 ug
EUR 565.2

anti-CKMM (3C3)

LF-MA0399 100 ul
EUR 400.8
Description: Mouse monoclonal to CKMM

anti-CKMM (11B11)

LF-MA0400 100 ul
EUR 400.8
Description: Mouse monoclonal to CKMM

  Rat CK-MM

1800-2 0.1 mg
EUR 200

  Pig CK-MM

1800-3 0.1 mg
EUR 200

  Mouse CK-MM

1800-1 0.1 mg
EUR 200

Rat CK-MM ELISA

KT-551 96 tests
EUR 595

Pig CK-MM ELISA

KT-552 96 tests
EUR 595

CK-MM Protein

abx060278-100ug 100 ug
EUR 910.8

Rat CK-MM ELISA Kit

ERC0407 96Tests
EUR 625.2

CK-MM Antigen

E64C00703 100ug
EUR 1620

CK-MM Antibody

abx022710-1mg 1 mg
EUR 886.8

CK-MM Antibody

abx022712-1mg 1 mg
EUR 577.2

CK-MM Antibody

abx022713-1ml 1 ml
EUR 444

CK-MM Antibody

abx020743-1mg 1 mg
EUR 577.2

CK-MM Antibody

abx020744-1mg 1 mg
EUR 526.8

Goat CK-MM ELISA Kit

EGTC0407 96Tests
EUR 625.2

CK-MM Type I Protein

abx069790-1mg 1 mg
EUR 886.8

Mouse CK-MM ELISA Kit

EMC0407 96Tests
EUR 625.2

Sheep CK-MM ELISA Kit

ESC0407 96Tests
EUR 625.2

Human CK-MM ELISA Kit

EHC0407 96Tests
EUR 625.2

Human(CK-MM) ELISA Kit

QY-E05359 96T
EUR 433.2

CK-MM Type III Protein

abx069791-1mg 1 mg
EUR 886.8

Monkey CK-MM ELISA Kit

EMKC0407 96Tests
EUR 625.2

Bovine CK-MM ELISA Kit

EBC0407 96Tests
EUR 625.2

Canine CK-MM ELISA Kit

ECC0407 96Tests
EUR 625.2

Porcine CK-MM ELISA Kit

EPC0407 96Tests
EUR 625.2

Nori® Human CK-MM ELISA Kit

GR111506 96-well
EUR 461

Chicken CK-MM ELISA Kit

ECKC0407 96Tests
EUR 625.2

Guinea Pig CK-MM ELISA Kit

EGC0407 96Tests
EUR 625.2

Ck-Mm Antigen Grade Protein

abx060710-1mg 1 mg
EUR 777.6

Human Creatine Kinase MM (CK-MM)

RP-1063 100 ug
EUR 343.2

OAMA01375-1MG - CK-MM Antibody

OAMA01375-1MG 1mg
EUR 359

OAMA01376-1MG - CK-MM Antibody

OAMA01376-1MG 1mg
EUR 299

anti-Creatine kinase-MM(CK-MM) (2C5)

LF-MA0234 100 ul
EUR 400.8
Description: Mouse monoclonal to Creatine kinase-MM(CK-MM)

OPMA04784-1MG - CK-MM Type I Protein

OPMA04784-1MG 1mg
EUR 669

OPMA04785-1MG - CK-MM Type III Protein

OPMA04785-1MG 1mg
EUR 799

Rat Creatine Kinase MM isoenzyme, CK-MM ELISA Kit

CSB-E14405r-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Creatine Kinase MM isoenzyme, CK-MM in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Creatine Kinase MM isoenzyme, CK-MM ELISA Kit

1-CSB-E14405r
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Creatine Kinase MM isoenzyme, CK-MM in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

YLA1738RA-48T 48T
EUR 465

Rat Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

YLA1738RA-96T 96T
EUR 600

Rat Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

EKC38912-48T 48T
EUR 535.99

Rat Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

EKC38912-5x96T 5x96T
EUR 3637.08

Rat Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

EKC38912-96T 96T
EUR 765.7

Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit

CSB-E18038h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Creatine Kinase MM isoenzyme (CK-MM) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit

1-CSB-E18038h
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Creatine Kinase MM isoenzyme(CK-MM) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Creatine Kinase MM isoenzyme, CK-MM ELISA Kit

CSB-E14407m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Creatine Kinase MM isoenzyme, CK-MM in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Creatine Kinase MM isoenzyme, CK-MM ELISA Kit

1-CSB-E14407m
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Creatine Kinase MM isoenzyme, CK-MM in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit

SL0680Mo -
EUR 528

Human Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

YLA0595HU-48T 48T
EUR 435

Human Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

YLA0595HU-96T 96T
EUR 562.5

Mouse Creatine Kinase MM isoenzyme(CK-MM) Elisa Kit

EK730427 96 Wells
EUR 0.68

Human Creatine Kinase MM isoenzyme(CK-MM) Elisa Kit

EK711916 96 Wells
EUR 0.22

Mouse Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

YLA1902MO-48T 48T
EUR 465

Mouse Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

YLA1902MO-96T 96T
EUR 600

Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit

EKC33304-48T 48T
EUR 597.24

Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit

EKC33304-5x96T 5x96T
EUR 4052.7

Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit

EKC33304-96T 96T
EUR 853.2

Mouse Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

EKC36674-48T 48T
EUR 535.99

Mouse Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

EKC36674-5x96T 5x96T
EUR 3637.08

Mouse Creatine Kinase MM isoenzyme,CK-MM ELISA Kit

EKC36674-96T 96T
EUR 765.7

Rat Creatine Kinase MM isoEnzyme, CK-MM GENLISA ELISA

KLR1930 1 x 96 wells
EUR 341

Mouse Creatine Kinase MM isoEnzyme, CK-MM GENLISA ELISA

KLM1979 1 x 96 wells
EUR 341

Human Creatine Kinase MM Isoenzyme, CK-MM GENLISA ELISA

KBH3377 1 x 96 wells
EUR 286

Recombinant Human Creatine Kinase MM (CK-MM) Type 3 Isoenzyme

DAG278 1KU
EUR 1095.6

Recombinant Human Creatine Kinase MM (CK-MM) Type I Isoenzyme

DAG281 1mg
EUR 1204.8

OPEF01611-1MG - Recombinant Creatine Kinase MM (CK-MM) Antigen

OPEF01611-1MG 1mg
EUR 792

9-Ethynyl-9-fluorenol

E16555 10G
EUR 237.18

Calpain 9 (Calpain 9) Antibody

abx231218-100ug 100 ug
EUR 577.2

Frizzled 9 (Frizzled 9) Antibody

abx233223-100ug 100 ug
EUR 577.2

Frizzled 9 (Frizzled 9) Antibody

20-abx121993
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Calpain 9 (Calpain 9) Antibody

20-abx111332
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Frizzled 9 (Frizzled 9) Antibody

20-abx008534
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Matrix Metalloproteinase 9 (MMP-9)

GT15020 100 ug
EUR 631.2

IL-9, Interleukin-9, human

RC212-20 10ug
EUR 203.56

Human Keratin- associated protein 9- 9, KRTAP9-9 ELISA KIT

ELI-38944h 96 Tests
EUR 988.8

KRTAP9 (untagged)-Human keratin associated protein 9-9 (KRTAP9-9)

SC317035 10 µg Ask for price

Angiotensin 1-9 (Ang1-9) Antibody

20-abx132109
  • EUR 410.40
  • EUR 1062.00
  • EUR 543.60
  • EUR 184.80
  • EUR 326.40
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Matrix Metalloproteinase 9 (MMP-9) Antibody

abx414532-02mg 0.2 mg
EUR 760.8

Matrix Metalloproteinase 9 (MMP-9) Antibody

abx414533-01mg 0.1 mg
EUR 526.8

Mouse Galectin-9 (Gal-9) Antibody

32253-05111 150 ug
EUR 313.2

Human Interleukin-9 (IL-9) Antibody

32578-05111 150 ug
EUR 313.2

Rat Angiotensin 1-9(Ang1-9)

QY-E11784 96T
EUR 448.8

Human 19-9(CA19-9)ELISA

QY-E05335 96T
EUR 448.8

9 9-Bis(3-Aminopropyl)fluorene

B11740 1G
EUR 231.73

9-deoxy-9-methylene Prostaglandin E2

T36728-10mg 10mg Ask for price
Description: 9-deoxy-9-methylene Prostaglandin E2

9-deoxy-9-methylene Prostaglandin E2

T36728-1g 1g Ask for price
Description: 9-deoxy-9-methylene Prostaglandin E2

9-deoxy-9-methylene Prostaglandin E2

T36728-1mg 1mg Ask for price
Description: 9-deoxy-9-methylene Prostaglandin E2

9-deoxy-9-methylene Prostaglandin E2

T36728-50mg 50mg Ask for price
Description: 9-deoxy-9-methylene Prostaglandin E2

Understanding the functional mechanism involved in the development of bone abnormality could open new horizons in the treatment of osteoporosis, by affecting the Wnt-SP. The design of antibodies to sclerostin, a Wnt-SP inhibitor, is most promising now. The paper summarizes the studies that have investigated the canonical Wnt-SP and designed drugs to treat osteoporosis.