Control of B-cell signaltransduction is critical to prevent production of pathological autoantibodies. Tandem PH domain containing proteins (TAPPs) specifically bind PI(3,4)P2, a phosphoinositide product generated by PI 3-kinases and the phosphatase SHIP. TAPP KI mice bearing PH domain-inactivating mutations in both TAPP1 and TAPP2 genes, uncoupling them from PI(3,4)P2, exhibit increased BCR-induced activation of the kinase Akt and develop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys.
Here, we find that TAPP KI mice develop chronic germinal centers (GCs) with age and show abnormal expression of B-cell activation and memory markers. Upon immunization with T-dependent Ag, TAPP KI mice develop functional but abnormally large GCs, associated with increased GC B-cell survival. Disruption of chronic GCs in TAPP KI mice by deletion of the costimulatory molecule ICOS abrogate anti-DNA and anti-nuclear antibody production in TAPP KI mice, indicating an essential role for GCs.
CKMM protein |
30-AC61 |
Fitzgerald |
100 ug |
EUR 325.2 |
Description: Purified recombinant CKMM protein |
CKMM protein |
30-1083 |
Fitzgerald |
1000 units |
EUR 949.2 |
Description: Purified native Human CKMM protein |
CKMM protein |
30-1084U |
Fitzgerald |
100 units |
EUR 334.8 |
Description: Highly pure native Human CKMM protein |
CKMM antibody |
10-C41A |
Fitzgerald |
1 mg |
EUR 594 |
Description: Mouse monoclonal CKMM antibody |
CKMM antibody |
10-C41B |
Fitzgerald |
1 mg |
EUR 454.8 |
Description: Mouse monoclonal CKMM antibody |
CKMM antibody |
10C-CR3014M1 |
Fitzgerald |
1 mg |
EUR 594 |
Description: Mouse monoclonal CKMM antibody |
CKMM antibody |
10C-CR3014M2 |
Fitzgerald |
1 mg |
EUR 454.8 |
Description: Mouse monoclonal CKMM antibody |
CKMM antibody |
10C-CR3014M3 |
Fitzgerald |
1 mg |
EUR 594 |
Description: Mouse monoclonal CKMM antibody |
CKMM antibody |
10R-8516 |
Fitzgerald |
100 ul |
EUR 471.6 |
Description: Mouse monoclonal CKMM antibody |
CKMM antibody |
20C-CR3014G |
Fitzgerald |
1 ml |
EUR 270 |
Description: Goat polyclonal CKMM antibody |
CKMM antibody |
20-CG75 |
Fitzgerald |
1 ml |
EUR 207.6 |
Description: Goat polyclonal CKMM antibody |
CKMM antibody |
20-CR75 |
Fitzgerald |
1 ml |
EUR 207.6 |
Description: Rabbit polyclonal CKMM antibody |
CKMM antibody |
70-XG47 |
Fitzgerald |
1 mg |
EUR 388.8 |
Description: Affinity purified Goat polyclonal CKMM antibody |
CKMM antibody |
70R-15270 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Rabbit polyclonal CKMM antibody |
CKMM antibody |
70R-33149 |
Fitzgerald |
100 ug |
EUR 522 |
Description: Rabbit polyclonal CKMM antibody |
CKMM antibody |
70R-1984 |
Fitzgerald |
50 ug |
EUR 560.4 |
Description: Rabbit polyclonal CKMM antibody raised against the N terminal of CKM |
CKMM antibody |
70R-1985 |
Fitzgerald |
50 ug |
EUR 560.4 |
Description: Rabbit polyclonal CKMM antibody raised against the middle region of CKM |
CKMM antibody |
20R-CK004 |
Fitzgerald |
1 L |
Ask for price |
|
Description: Goat polyclonal CKMM antiserum |
CKMM antibody |
70R-CG004 |
Fitzgerald |
1 G |
Ask for price |
|
Description: Affinity purified Goat polyclonal CKMM antibody |
CKMM antibody (HRP) |
60R-1648 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Rabbit polyclonal CKMM antibody (HRP) |
Rat CKMM Antibody |
32939-05111 |
AssayPro |
150 ug |
EUR 313.2 |
CKMM antibody (FITC) |
60R-1649 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Rabbit polyclonal CKMM antibody (FITC) |
Mouse CKMM Antibody |
32938-05111 |
AssayPro |
150 ug |
EUR 313.2 |
CKMM antibody (biotin) |
60R-1650 |
Fitzgerald |
100 ug |
EUR 418.8 |
Description: Rabbit polyclonal CKMM antibody (biotin) |
CKMM Blocking Peptide |
33R-9549 |
Fitzgerald |
100 ug |
EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1984 |
CKMM Blocking Peptide |
33R-3630 |
Fitzgerald |
100 ug |
EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1985 |
CKMM Type 1 protein |
30R-AC026 |
Fitzgerald |
1 mg |
EUR 949.2 |
Description: Purified recombinant CKMM Type 1 protein |
Human ckmm PicoKine ELISA Kit |
EK1751 |
BosterBio |
96 wells |
EUR 510 |
Description: For quantitative detection of human ckmm in cell culture supernates, serum and plasma (heparin, EDTA). |
Rat CKMM Antibody (Biotin Conjugate) |
32939-05121 |
AssayPro |
150 ug |
EUR 442.8 |
Mouse CKMM Antibody (Biotin Conjugate) |
32938-05121 |
AssayPro |
150 ug |
EUR 442.8 |
Rat CKMM AssayLite Antibody (APC Conjugate) |
32939-05161 |
AssayPro |
150 ug |
EUR 513.6 |
Rat CKMM AssayLite Antibody (FITC Conjugate) |
32939-05141 |
AssayPro |
150 ug |
EUR 513.6 |
Rat CKMM AssayLite Antibody (RPE Coinjugate) |
32939-05151 |
AssayPro |
150 ug |
EUR 513.6 |
Mouse CKMM AssayLite Antibody (RPE Conjugate) |
32938-05151 |
AssayPro |
150 ug |
EUR 513.6 |
Mouse CKMM AssayLite Antibody (APC Conjugate) |
32938-05161 |
AssayPro |
150 ug |
EUR 513.6 |
Rat CKMM AssayLite Antibody (PerCP Conjugate) |
32939-05171 |
AssayPro |
150 ug |
EUR 565.2 |
Mouse CKMM AssayLite Antibody (FITC Conjugate) |
32938-05141 |
AssayPro |
150 ug |
EUR 513.6 |
Recombinant Human CKMM/CKM Protein, His Tag |
E40KMH880 |
EnoGene |
20ug |
EUR 495 |
Mouse CKMM AssayLite Antibody (PerCP Conjugate) |
32938-05171 |
AssayPro |
150 ug |
EUR 565.2 |
Human Creatine Kinase, Muscle(CKMM) Elisa Kit |
EK700626 |
AFG Bioscience LLC |
96 Wells |
EUR 0.5 |
Human Creatine Kinase M-type (CKMM) Antibody |
11281-05011 |
AssayPro |
150 ug |
EUR 260.4 |
Recombinant Human Creatine Kinase MM/CKMM Protein |
RP02817LQ |
Abclonal |
50μg |
EUR 58.5 |
|
Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His) |
CC96-10ug |
Novoprotein |
10ug |
EUR 169.2 |
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5. |
Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His) |
CC96-1mg |
Novoprotein |
1mg |
EUR 2008.8 |
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5. |
Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His) |
CC96-500ug |
Novoprotein |
500ug |
EUR 1423.2 |
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5. |
Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His) |
CC96-50ug |
Novoprotein |
50ug |
EUR 315.6 |
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5. |
Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His) |
AP75592 |
SAB |
1mg |
EUR 2369 |
|
Human Creatine Kinase M-type (CKMM) Antibody (Biotin Conjugate) |
11281-05021 |
AssayPro |
150 ug |
EUR 331.2 |
Human Creatine Kinase M-type (CKMM) AssayLite Antibody (RPE Conjugate) |
11281-05051 |
AssayPro |
150 ug |
EUR 513.6 |
Human Creatine Kinase M-type (CKMM) AssayLite Antibody (APC Conjugate) |
11281-05061 |
AssayPro |
150 ug |
EUR 513.6 |
Human Creatine Kinase M-type (CKMM) AssayLite Antibody (FITC Conjugate) |
11281-05041 |
AssayPro |
150 ug |
EUR 513.6 |
Human Creatine Kinase M-type (CKMM) AssayLite Antibody (PerCP Conjugate) |
11281-05071 |
AssayPro |
150 ug |
EUR 565.2 |
anti-CKMM (3C3) |
LF-MA0399 |
Abfrontier |
100 ul |
EUR 400.8 |
Description: Mouse monoclonal to CKMM |
anti-CKMM (11B11) |
LF-MA0400 |
Abfrontier |
100 ul |
EUR 400.8 |
Description: Mouse monoclonal to CKMM |
CK-MM Protein |
abx060278-100ug |
Abbexa |
100 ug |
EUR 910.8 |
|
Rat CK-MM ELISA Kit |
ERC0407 |
Abclonal |
96Tests |
EUR 625.2 |
CK-MM Antigen |
E64C00703 |
EnoGene |
100ug |
EUR 1620 |
CK-MM Antibody |
abx022710-1mg |
Abbexa |
1 mg |
EUR 886.8 |
|
CK-MM Antibody |
abx022712-1mg |
Abbexa |
1 mg |
EUR 577.2 |
|
CK-MM Antibody |
abx022713-1ml |
Abbexa |
1 ml |
EUR 444 |
|
CK-MM Antibody |
abx020743-1mg |
Abbexa |
1 mg |
EUR 577.2 |
|
CK-MM Antibody |
abx020744-1mg |
Abbexa |
1 mg |
EUR 526.8 |
|
Goat CK-MM ELISA Kit |
EGTC0407 |
Abclonal |
96Tests |
EUR 625.2 |
CK-MM Type I Protein |
abx069790-1mg |
Abbexa |
1 mg |
EUR 886.8 |
|
Mouse CK-MM ELISA Kit |
EMC0407 |
Abclonal |
96Tests |
EUR 625.2 |
Sheep CK-MM ELISA Kit |
ESC0407 |
Abclonal |
96Tests |
EUR 625.2 |
Human CK-MM ELISA Kit |
EHC0407 |
Abclonal |
96Tests |
EUR 625.2 |
CK-MM Type III Protein |
abx069791-1mg |
Abbexa |
1 mg |
EUR 886.8 |
|
Monkey CK-MM ELISA Kit |
EMKC0407 |
Abclonal |
96Tests |
EUR 625.2 |
Bovine CK-MM ELISA Kit |
EBC0407 |
Abclonal |
96Tests |
EUR 625.2 |
Canine CK-MM ELISA Kit |
ECC0407 |
Abclonal |
96Tests |
EUR 625.2 |
Porcine CK-MM ELISA Kit |
EPC0407 |
Abclonal |
96Tests |
EUR 625.2 |
Chicken CK-MM ELISA Kit |
ECKC0407 |
Abclonal |
96Tests |
EUR 625.2 |
Guinea Pig CK-MM ELISA Kit |
EGC0407 |
Abclonal |
96Tests |
EUR 625.2 |
Ck-Mm Antigen Grade Protein |
abx060710-1mg |
Abbexa |
1 mg |
EUR 777.6 |
|
anti-Creatine kinase-MM(CK-MM) (2C5) |
LF-MA0234 |
Abfrontier |
100 ul |
EUR 400.8 |
Description: Mouse monoclonal to Creatine kinase-MM(CK-MM) |
Rat Creatine Kinase MM isoenzyme, CK-MM ELISA Kit |
CSB-E14405r-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Rat Creatine Kinase MM isoenzyme, CK-MM in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat Creatine Kinase MM isoenzyme, CK-MM ELISA Kit |
1-CSB-E14405r |
Cusabio |
-
EUR 964.80
-
EUR 6118.80
-
EUR 3244.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat Creatine Kinase MM isoenzyme, CK-MM in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat Creatine Kinase MM isoenzyme,CK-MM ELISA Kit |
EKC38912-5x96T |
Biomatik Corporation |
5x96T |
EUR 3637.08 |
Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit |
CSB-E18038h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Creatine Kinase MM isoenzyme (CK-MM) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit |
1-CSB-E18038h |
Cusabio |
-
EUR 1080.00
-
EUR 6571.20
-
EUR 3480.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Creatine Kinase MM isoenzyme(CK-MM) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Creatine Kinase MM isoenzyme, CK-MM ELISA Kit |
CSB-E14407m-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Creatine Kinase MM isoenzyme, CK-MM in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Creatine Kinase MM isoenzyme, CK-MM ELISA Kit |
1-CSB-E14407m |
Cusabio |
-
EUR 964.80
-
EUR 6118.80
-
EUR 3244.80
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Creatine Kinase MM isoenzyme, CK-MM in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit |
SL0680Mo |
Sunlong |
- |
EUR 528 |
|
Human Creatine Kinase MM isoenzyme,CK-MM ELISA Kit |
YLA0595HU-48T |
Shanghai YL Biotech |
48T |
EUR 435 |
Human Creatine Kinase MM isoenzyme,CK-MM ELISA Kit |
YLA0595HU-96T |
Shanghai YL Biotech |
96T |
EUR 562.5 |
Mouse Creatine Kinase MM isoenzyme(CK-MM) Elisa Kit |
EK730427 |
AFG Bioscience LLC |
96 Wells |
EUR 0.68 |
Human Creatine Kinase MM isoenzyme(CK-MM) Elisa Kit |
EK711916 |
AFG Bioscience LLC |
96 Wells |
EUR 0.22 |
Mouse Creatine Kinase MM isoenzyme,CK-MM ELISA Kit |
YLA1902MO-48T |
Shanghai YL Biotech |
48T |
EUR 465 |
Mouse Creatine Kinase MM isoenzyme,CK-MM ELISA Kit |
YLA1902MO-96T |
Shanghai YL Biotech |
96T |
EUR 600 |
Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit |
EKC33304-48T |
Biomatik Corporation |
48T |
EUR 597.24 |
Human Creatine Kinase MM isoenzyme(CK-MM) ELISA Kit |
EKC33304-5x96T |
Biomatik Corporation |
5x96T |
EUR 4052.7 |
Mouse Creatine Kinase MM isoenzyme,CK-MM ELISA Kit |
EKC36674-5x96T |
Biomatik Corporation |
5x96T |
EUR 3637.08 |
Rat Creatine Kinase MM isoEnzyme, CK-MM GENLISA ELISA |
KLR1930 |
Krishgen |
1 x 96 wells |
EUR 341 |
Mouse Creatine Kinase MM isoEnzyme, CK-MM GENLISA ELISA |
KLM1979 |
Krishgen |
1 x 96 wells |
EUR 341 |
Human Creatine Kinase MM Isoenzyme, CK-MM GENLISA ELISA |
KBH3377 |
Krishgen |
1 x 96 wells |
EUR 286 |
Recombinant Human Creatine Kinase MM (CK-MM) Type 3 Isoenzyme |
DAG278 |
Creative Diagnostics |
1KU |
EUR 1095.6 |
Recombinant Human Creatine Kinase MM (CK-MM) Type I Isoenzyme |
DAG281 |
Creative Diagnostics |
1mg |
EUR 1204.8 |
OPEF01611-1MG - Recombinant Creatine Kinase MM (CK-MM) Antigen |
OPEF01611-1MG |
Aviva Systems Biology |
1mg |
EUR 792 |
|
CKMB Type-2 |
cki-270 |
ProSpec Tany |
10µg |
EUR 60 |
Description: Recombinant Human Creatine Kinase MB Isoenzyme Type-2 |
Moreover, TAPP KI B cells are sufficient to drive chronic GC responses and recapitulate the autoimmune phenotype in BM chimeric mice. Our findings demonstrate a B-cell-intrinsic role of TAPP-PI(3,4)P2 interaction in regulating GC responses and autoantibody production and suggest that uncontrolled Akt activity in B cells can drive autoimmunity.