Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice.

Lupus-prone (NZB × NZW)F1 female mice were prophylactically or therapeutically treated with the small-molecule Gβγ inhibitor gallein. Tissue samples were analyzed by flow cytometry and immunohistochemistry. The development and extent of nephritis were assessed by monitoring proteinuria and by immunohistochemical analysis.

Serum immunoglobulin levels were measured by enzyme-linked immunosorbent assay, and total IgG and anti-double-stranded DNA (anti-dsDNA) antibody-secreting cells were measured by enzyme-linked immunospot assay.Gallein inhibited accumulation of T cells and germinal center (GC) B cells in the spleen. Both prophylactic and therapeutic treatment reduced GC size, decreased antibody-secreting cell production in the spleen, and markedly decreased accumulation of autoreactive anti-dsDNA antibody-secreting cells in kidneys.

Gallein also reduced immune complex deposition in kidneys. Finally, gallein treatment dramatically inhibited kidney inflammation, prevented glomerular damage, and decreased proteinuria.

Human SMLR1 shRNA Plasmid
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ABC-KH14313 1 vial Ask for price
Description: Human SMLR1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

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Description: Human SMLR1 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human SMLR1 Protein Lysate 20ug
IHUSMLR1PLLY20UG each
EUR 213
Description: Human SMLR1 Protein Lysate 20ug

Lenti ORF particles, Lsm10 (GFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 2, 200ul, >10^7 TU/mL
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Human U6 snRNA-associated Sm-like protein LSm4 (LSM4)
1-CSB-EP013207HU
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  • 100ug
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Description: Recombinant Human U6 snRNA-associated Sm-like protein LSm4(LSM4) expressed in E.coli

Smlr1 (untagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik), (10ug)
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U6 SnRNA-Associated Sm-Like Protein LSm3 (LSM3) Protein
20-abx260874
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Human U7 snRNA-associated Sm-like protein LSm10 (LSM10)
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Description: Recombinant Human U7 snRNA-associated Sm-like protein LSm10(LSM10) expressed in E.coli

Smlr1 (GFP-tagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik), (10ug)
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Smlr1 (Myc-DDK-tagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik)
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U6 SnRNA-Associated Sm-Like Protein LSm6 (LSM6) Antibody (HRP)
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Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) ELISA Kit
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EUR 325
Description: Mouse (Mus musculus)

Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) ELISA Kit
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EUR 610
Description: Mouse (Mus musculus)

Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) ELISA Kit
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U6 SnRNA-Associated Sm-Like Protein LSm3 (LSM3) Antibody (FITC)
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ELISA kit for Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5)
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.0 .

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EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.0 .

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EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.0 .

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EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

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EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm1/LSM1 (C-6His)
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EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm1/LSM1 (C-6His)
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Lsm11 (untagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11), (10ug)
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Recombinant Human U7 snRNA-associated Sm-like protein LSm10 (LSM10)
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Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 (N-6His)
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Recombinant Human U7 snRNA-associated Sm-like protein LSm10(LSM10)
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Lenti ORF clone of Lsm11 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11)
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Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-1mg
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Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-100ug
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EUR 489.6

Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-10ug
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Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-500ug
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Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-100ug
QP7867-ec-100ug 100ug
EUR 489.6

Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-200ug
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Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-500ug
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Lsm10 (GFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10) transcript variant 1, (10ug)
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2'-Deoxy-2',2'-difluorouridine
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EUR 151.2

2'-Deoxy-2',2'-difluorouridine
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2',2'-Difluoro-2'-deoxyuridine
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2''-Deoxy-2'',2''-difluorouridine
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2-(2-Naphthyl)-2-pentyloxyethanenitrile
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Lenti ORF clone of Lsm10 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 1
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2, 2-Bipyridine
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2 2'-Methylenedithiophene_x000D__x000D_
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MI-2-2
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Description: MI-2-2

MI-2-2
T28036-1g 1g Ask for price
Description: MI-2-2

MI-2-2
T28036-1mg 1mg Ask for price
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MI-2-2
T28036-50mg 50mg Ask for price
Description: MI-2-2

MI-2-2
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Description: MI-2-2

2-[2-(2-Azidoethoxy)ethoxy]ethanamine
20-abx183041
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2-[2-(2-Chloroethoxy)Ethoxy]Ethanol
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2-[2-(2-Aminoethoxy)Ethoxy]Ethanol
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2-[2-(2-methoxyethoxy)ethoxy]ethylamine
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2-[2-(2-Azidoethoxy)Ethoxy]Ethanol
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2-(2-Bromophenyl)propan-2-amineHCl
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2-[2-(2-Propynyloxy)ethoxy]ethylamine
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2 2-Ethylenebis(2-thiopseudourea) dihydrobromide
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2-(2-Naphthyl)-2-(phenylmethoxy)-ethanenitrile
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Mechanistically, gallein inhibited immune cell migration and signaling in response to chemokines in vitro, which suggests that its mechanisms of action in vivo are inhibition of migration of immune cells to sites of inflammation and inhibition of immune cell maturation.