Lupus-prone (NZB × NZW)F1 female mice were prophylactically or therapeutically treated with the small-molecule Gβγ inhibitor gallein. Tissue samples were analyzed by flow cytometry and immunohistochemistry. The development and extent of nephritis were assessed by monitoring proteinuria and by immunohistochemical analysis.
Serum immunoglobulin levels were measured by enzyme-linked immunosorbent assay, and total IgG and anti-double-stranded DNA (anti-dsDNA) antibody-secreting cells were measured by enzyme-linked immunospot assay.Gallein inhibited accumulation of T cells and germinal center (GC) B cells in the spleen. Both prophylactic and therapeutic treatment reduced GC size, decreased antibody-secreting cell production in the spleen, and markedly decreased accumulation of autoreactive anti-dsDNA antibody-secreting cells in kidneys.
Gallein also reduced immune complex deposition in kidneys. Finally, gallein treatment dramatically inhibited kidney inflammation, prevented glomerular damage, and decreased proteinuria.
Human SMLR1 shRNA Plasmid |
20-abx968931 |
Abbexa |
|
|
|
Lenti ORF clone of Lsm10 (mGFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 2 |
MR200601L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Lsm10 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 2 |
MR200601L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Human SMLR1 knockout cell line |
ABC-KH14313 |
AcceGen |
1 vial |
Ask for price |
Description: Human SMLR1 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology. |
Human SMLR1 knockdown cell line |
ABC-KD14313 |
AcceGen |
1 vial |
Ask for price |
Description: Human SMLR1 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest. |
Human SMLR1 Protein Lysate 20ug |
IHUSMLR1PLLY20UG |
Innovative research |
each |
EUR 213 |
|
Description: Human SMLR1 Protein Lysate 20ug |
Lenti ORF particles, Lsm10 (GFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 2, 200ul, >10^7 TU/mL |
MR200601L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Lsm10 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 2, 200ul, >10^7 TU/mL |
MR200601L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Human U6 snRNA-associated Sm-like protein LSm4 (LSM4) |
1-CSB-EP013207HU |
Cusabio |
-
EUR 456.00
-
EUR 256.80
-
EUR 1570.80
-
EUR 672.00
-
EUR 1047.60
-
EUR 314.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human U6 snRNA-associated Sm-like protein LSm4(LSM4) expressed in E.coli |
Smlr1 (untagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik), (10ug) |
MC211669 |
Origene Technologies GmbH |
10 µg |
Ask for price |
U6 SnRNA-Associated Sm-Like Protein LSm3 (LSM3) Protein |
20-abx260874 |
Abbexa |
-
EUR 4101.60
-
EUR 393.60
-
EUR 276.00
|
|
|
Human U7 snRNA-associated Sm-like protein LSm10 (LSM10) |
1-CSB-EP836169HU |
Cusabio |
-
EUR 456.00
-
EUR 256.80
-
EUR 1570.80
-
EUR 672.00
-
EUR 1047.60
-
EUR 314.40
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human U7 snRNA-associated Sm-like protein LSm10(LSM10) expressed in E.coli |
Smlr1 (GFP-tagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik), (10ug) |
MG226437 |
Origene Technologies GmbH |
10 µg |
Ask for price |
U6 SnRNA-Associated Sm-Like Protein LSm6 (LSM6) Antibody |
abx038015-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
U6 SnRNA-Associated Sm-Like Protein LSm6 (LSM6) Antibody |
abx432211-200ul |
Abbexa |
200 ul |
EUR 343.2 |
|
U6 SnRNA-Associated Sm-Like Protein LSm3 (LSM3) Antibody |
20-abx304389 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
U6 SnRNA-Associated Sm-Like Protein LSm6 (LSM6) Antibody |
20-abx304396 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Smlr1 (Myc-DDK-tagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik) |
MR226437 |
Origene Technologies GmbH |
10 µg |
Ask for price |
U6 SnRNA-Associated Sm-Like Protein LSm3 (LSM3) Antibody (HRP) |
20-abx304390 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
U6 SnRNA-Associated Sm-Like Protein LSm6 (LSM6) Antibody (HRP) |
20-abx304397 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) ELISA Kit |
AE60531MO-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
Description: Mouse (Mus musculus) |
Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) ELISA Kit |
AE60531MO-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
Description: Mouse (Mus musculus) |
Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) ELISA Kit |
EK11518 |
SAB |
96Т |
EUR 799 |
|
U6 SnRNA-Associated Sm-Like Protein LSm3 (LSM3) Antibody (FITC) |
20-abx304391 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
U6 SnRNA-Associated Sm-Like Protein LSm6 (LSM6) Antibody (FITC) |
20-abx304398 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
ELISA kit for Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) |
KTE71470-48T |
Abbkine |
48T |
EUR 398.4 |
|
Description: Quantitative sandwich ELISA for measuring Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) |
KTE71470-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2538 |
|
Description: Quantitative sandwich ELISA for measuring Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) |
KTE71470-96T |
Abbkine |
96T |
EUR 646.8 |
|
Description: Quantitative sandwich ELISA for measuring Mouse U6 snRNA-associated Sm-like protein LSm5 (LSM5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
U6 SnRNA-Associated Sm-Like Protein LSm3 (LSM3) Antibody (Biotin) |
20-abx304392 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
U6 SnRNA-Associated Sm-Like Protein LSm6 (LSM6) Antibody (Biotin) |
20-abx304399 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Lenti ORF clone of Smlr1 (mGFP-tagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik) |
MR226437L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Recombinant Human U6 snRNA-associated Sm-like protein LSm4 (LSM4) |
CSB-EP013207HU |
Cusabio |
1636 mg |
Ask for price |
Recombinant Human U6 snRNA-associated Sm-like protein LSm4(LSM4) |
AP70516 |
SAB |
1mg |
EUR 1978 |
|
Lsm10 (GFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10) |
MG200601 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lsm11 (GFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11) |
MG205525 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Smlr1 (Myc-DDK-tagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik) |
MR226437L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 (N-6His) |
C230-10ug |
Novoprotein |
10ug |
EUR 242.4 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.0 . |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 (N-6His) |
C230-1mg |
Novoprotein |
1mg |
EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.0 . |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 (N-6His) |
C230-500ug |
Novoprotein |
500ug |
EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.0 . |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 (N-6His) |
C230-50ug |
Novoprotein |
50ug |
EUR 595.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, pH 8.0 . |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm1/LSM1 (C-6His) |
C262-10ug |
Novoprotein |
10ug |
EUR 242.4 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm1/LSM1 (C-6His) |
C262-1mg |
Novoprotein |
1mg |
EUR 2739.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm1/LSM1 (C-6His) |
C262-500ug |
Novoprotein |
500ug |
EUR 1935.6 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm1/LSM1 (C-6His) |
C262-50ug |
Novoprotein |
50ug |
EUR 595.2 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
Lsm11 (untagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11), (10ug) |
MC211312 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Recombinant Human U7 snRNA-associated Sm-like protein LSm10 (LSM10) |
CSB-EP836169HU |
Cusabio |
4267 mg |
Ask for price |
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm4/LSM4 (N-6His) |
AP74962 |
SAB |
1mg |
EUR 3209 |
|
Recombinant Human U6 snRNA-Associated Sm-Like Protein LSm1/LSM1 (C-6His) |
AP74994 |
SAB |
1mg |
EUR 3209 |
|
Recombinant Human U7 snRNA-associated Sm-like protein LSm10(LSM10) |
AP71415 |
SAB |
1mg |
EUR 1978 |
|
Lsm11 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11) |
MR205525 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF particles, Smlr1 (GFP-tagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik), 200ul, >10^7 TU/mL |
MR226437L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Smlr1 (Myc-DDK-tagged) - Mouse RIKEN cDNA 2010003K15 gene (2010003K15Rik), 200ul, >10^7 TU/mL |
MR226437L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF clone of Lsm11 (mGFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11) |
MR205525L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti-ORF clone of SMLR1 (mGFP-tagged)-Human hypothetical LOC285733 (LOC285733) |
RC230944L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Lsm11 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11) |
MR205525L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti-ORF clone of SMLR1 (Myc-DDK-tagged)-Human hypothetical LOC285733 (LOC285733) |
RC230944L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-1mg |
QP6322-ec-1mg |
EnQuireBio |
1mg |
EUR 1958.4 |
Lenti ORF particles, SMLR1 (mGFP-tagged)-Human hypothetical LOC285733 (LOC285733), 200ul, >10^7 TU/mL |
RC230944L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-100ug |
QP6322-ec-100ug |
EnQuireBio |
100ug |
EUR 489.6 |
Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-10ug |
QP6322-ec-10ug |
EnQuireBio |
10ug |
EUR 240 |
Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-200ug |
QP6322-ec-200ug |
EnQuireBio |
200ug |
EUR 760.8 |
Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-500ug |
QP6322-ec-500ug |
EnQuireBio |
500ug |
EUR 1272 |
Recombinant Human U6 snRNA-associated Sm-like protein LSm4 Protein, His-SUMO, E.coli-50ug |
QP6322-ec-50ug |
EnQuireBio |
50ug |
EUR 315.6 |
Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-10ug |
QP7867-ec-10ug |
EnQuireBio |
10ug |
EUR 240 |
Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-1mg |
QP7867-ec-1mg |
EnQuireBio |
1mg |
EUR 1958.4 |
Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-50ug |
QP7867-ec-50ug |
EnQuireBio |
50ug |
EUR 315.6 |
Lsm10 (untagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 1, (10ug) |
MC204183 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lsm10 (untagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 1, (10ug) |
MC207206 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF particles, Lsm11 (GFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11), 200ul, >10^7 TU/mL |
MR205525L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, SMLR1 (Myc-DDK-tagged)-Human hypothetical LOC285733 (LOC285733), 200ul, >10^7 TU/mL |
RC230944L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-100ug |
QP7867-ec-100ug |
EnQuireBio |
100ug |
EUR 489.6 |
Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-200ug |
QP7867-ec-200ug |
EnQuireBio |
200ug |
EUR 760.8 |
Recombinant Human U7 snRNA-associated Sm-like protein LSm10 Protein, His-SUMO, E.coli-500ug |
QP7867-ec-500ug |
EnQuireBio |
500ug |
EUR 1272 |
Lsm10 (GFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10) transcript variant 1, (10ug) |
MG216351 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF particles, Lsm11 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM11 (Lsm11), 200ul, >10^7 TU/mL |
MR205525L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lsm10 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 1 |
MR216351 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Lsm10 (Myc-DDK-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 1 |
MR216351L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Lsm10 (mGFP-tagged) - Mouse U7 snRNP-specific Sm-like protein LSM10 (Lsm10), transcript variant 1 |
MR216351L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
2, 2-Bipyridine |
BD1219 |
Bio Basic |
10g |
EUR 85.06 |
|
2 2'-Methylenedithiophene_x000D__x000D_ |
M17340 |
Pfaltz & Bauer |
500MG |
EUR 4968.5 |
2 2-Dimethylbiphenyl_x000D__x000D_ |
D38280 |
Pfaltz & Bauer |
500MG |
EUR 652.05 |
2-[2-(2-Azidoethoxy)ethoxy]ethanamine |
20-abx183041 |
Abbexa |
|
|
|
2-[2-(2-Chloroethoxy)Ethoxy]Ethanol |
20-abx185012 |
Abbexa |
|
|
|
2-[2-(2-Aminoethoxy)Ethoxy]Ethanol |
abx186612-1g |
Abbexa |
1 g |
EUR 360 |
|
2-[2-(2-methoxyethoxy)ethoxy]ethylamine |
20-abx187843 |
Abbexa |
|
|
|
2-[2-(2-Azidoethoxy)Ethoxy]Ethanol |
20-abx187846 |
Abbexa |
|
|
|
2-(2-Bromophenyl)propan-2-amineHCl |
20-abx180203 |
Abbexa |
|
|
|
2-[2-(2-Propynyloxy)ethoxy]ethylamine |
20-abx180263 |
Abbexa |
|
|
|
2 2-Ethylenebis(2-thiopseudourea) dihydrobromide |
E08235 |
Pfaltz & Bauer |
10G |
EUR 254.61 |
2-(2 2-Dicarbethoxyvinylamino)-6-methylpyridine |
D12730 |
Pfaltz & Bauer |
10G |
EUR 320.13 |
Mechanistically, gallein inhibited immune cell migration and signaling in response to chemokines in vitro, which suggests that its mechanisms of action in vivo are inhibition of migration of immune cells to sites of inflammation and inhibition of immune cell maturation.