Chemosensory signal transduction in Caenorhabditis elegans

Chemosensory signal transduction in Caenorhabditis elegans

Chemosensory neurons translate notion of exterior chemical cues, together with odorants, tastants, and pheromones, into info that drives attraction or avoidance motor applications. Within the laboratory, strong behavioral assays, coupled with highly effective genetic, molecular and optical instruments, have made Caenorhabditis elegans a perfect experimental system wherein to dissect the contributions of particular person genes and neurons to ethologically related chemosensory behaviors. Right here, we evaluation present information of the neurons, sign transduction molecules and regulatory mechanisms that underlie the response of C. elegans to chemical compounds, together with pheromones.

The vast majority of recognized molecules and pathways share exceptional homology with sensory mechanisms in different organisms. With the event of recent instruments and applied sciences, we anticipate that continued examine of chemosensory sign transduction and processing in C. elegans will yield further new insights into the mechanisms by which this animal is ready to detect and discriminate amongst hundreds of chemical cues with a restricted sensory neuron repertoire. Lymphoma is a heterogeneous group of malignancies, which contains 4.2 % of all new most cancers instances and three.3 % of all most cancers deaths in 2019, globally.

The dysregulation of immune system, sure bacterial or viral infections, autoimmune illnesses, and immune suppression are related to a excessive threat of lymphoma. Though a number of standard methods have improved throughout the previous few many years, however their detrimental impacts stay an impediment to be resolved. Nonetheless, pure compounds are thought-about a great choice within the remedy of lymphomas due to their straightforward accessibility, particular mode of motion, excessive biodegradability, and cost-effectiveness. Greens, fruits, and drinks are the first sources of pure energetic compounds.

The current evaluation investigated the actions of various pure medicinal compounds together with curcumin, MK615, resveratrol, bromelain, EGCG, and Annonaceous acetogenins to deal with lymphomas. Furthermore, in vitro and in vivo research, classification, threat elements, and prognosis of lymphoma are additionally mentioned within the current evaluation. The collected information proposed that pure compounds regulate the signaling pathways on the stage of cell proliferation, apoptosis, and cell cycle to exhibit anti-lymphoma actions each in-vivo and in-vitro research and instructed that these energetic compounds could possibly be a great therapeutic choice within the remedy of various kinds of lymphomas.

Function of Adenosine and Purinergic Receptors in Myocardial Infarction: Give attention to Totally different Sign Transduction Pathways

Myocardial infarction (MI) is a dramatic occasion usually attributable to atherosclerotic plaque erosion or rupture and subsequent thrombotic occlusion of a coronary vessel. The low provide of oxygen and vitamins within the infarcted space might end in cardiomyocytes necrosis, alternative of intact myocardium with non-contractile fibrous tissue and left ventricular (LV) operate impairment if blood stream will not be shortly restored. On this evaluation, we summarized the doable correlation between adenosine system, purinergic system and Wnt/β-catenin pathway and their function within the pathogenesis of cardiac harm following MI.

On this context, a number of pathways are concerned and, specifically, the adenosine receptors system exhibits totally different interactions between its members and purinergic receptors: their modulation is likely to be efficient not solely for a traditional practical restoration but additionally for the remedy of coronary heart illnesses, thus avoiding fibrosis, lowering infarcted space and limiting scaring. Equally, it has been proven that Wnt/β catenin pathway is activated following myocardial harm and its unbalanced activation may promote cardiac fibrosis and, consequently, LV systolic operate impairment.

Chemosensory signal transduction in Caenorhabditis elegans

A multiplier peroxiporin sign transduction pathway powers piscine spermatozoa

The first job of a spermatozoon is to ship its nuclear payload to the egg to type the next-generation zygote. With polyandry repeatedly evolving within the animal kingdom, nevertheless, sperm competitors has change into widespread, with the best recognized intensities occurring in fish. But, the molecular controls regulating spermatozoon swimming efficiency in these organisms are largely unknown. Right here, we present that the kinematic properties of postactivated piscine spermatozoa are regulated by means of a conserved trafficking mechanism whereby a peroxiporin ortholog of mammalian aquaporin-8 (Aqp8bb) is inserted into the interior mitochondrial membrane to facilitate H2O2 efflux with the intention to keep ATP manufacturing.

In teleosts from extra ancestral lineages, such because the zebrafish (Danio rerio) and the Atlantic salmon (Salmo salar), wherein spermatozoa are activated in freshwater, an intracellular Ca2+-signaling immediately regulates this mechanism by means of monophosphorylation of the Aqp8bb N terminus. In distinction, in additional not too long ago advanced marine teleosts, such the gilthead seabream (Sparus aurata), wherein spermatozoa activation happens in seawater, a cross-talk between Ca2+– and oxidative stress-activated pathways generate a multiplier regulation of channel trafficking by way of twin N-terminal phosphorylation. These findings reveal that teleost spermatozoa advanced more and more subtle cleansing pathways to take care of swimming efficiency beneath a excessive osmotic stress, and supply perception into molecular traits which might be advantageous for postcopulatory sexual choice.

Human signal transduction-Smad7 ELISA Kit

CN-03385H1 96T
EUR 448

Human signal transduction-Smad7 ELISA Kit

CN-03385H2 48T
EUR 297

Rat signal transduction-Smad7 ELISA Kit

CN-01426R1 96T
EUR 442

Rat signal transduction-Smad7 ELISA Kit

CN-01426R2 48T
EUR 293

Human Signal Transduction Primer Library

HSTL-I 1 set
EUR 450

QuantiSir Specific Gene Knockdown Quantification Kit For Signal Transduction - ViDR

P-5008 96 Assays
EUR 788.05
Description: Ask the seller for details

Human Signal transduction protein CBL- C, CBLC ELISA KIT

ELI-50273h 96 Tests
EUR 824

Mouse Signal transduction protein CBL- C, Cblc ELISA KIT

ELI-33118m 96 Tests
EUR 865

Human Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

RD-Smad1-Hu-48Tests 48 Tests
EUR 478

Human Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

RD-Smad1-Hu-96Tests 96 Tests
EUR 662

Rat Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

RD-Smad1-Ra-48Tests 48 Tests
EUR 511

Rat Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

RD-Smad1-Ra-96Tests 96 Tests
EUR 709

Human Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

DLR-Smad1-Hu-48T 48T
EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Mothers Against Decapentaplegic Homolog 1 (Smad1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

DLR-Smad1-Hu-96T 96T
EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Mothers Against Decapentaplegic Homolog 1 (Smad1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

DLR-Smad1-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Mothers Against Decapentaplegic Homolog 1 (Smad1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

DLR-Smad1-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Mothers Against Decapentaplegic Homolog 1 (Smad1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

RDR-Smad1-Hu-48Tests 48 Tests
EUR 500

Human Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

RDR-Smad1-Hu-96Tests 96 Tests
EUR 692

Rat Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

RDR-Smad1-Ra-48Tests 48 Tests
EUR 534

Rat Mothers Against Decapentaplegic Homolog 1 (Smad1) ELISA Kit

RDR-Smad1-Ra-96Tests 96 Tests
EUR 742

Anti-ERK1 (E32) Signal Transduction Monoclonal Antibody

ABP-MAB-ES001 100 ug Ask for price

Anti-ERK1 (E19) Signal Transduction Monoclonal Antibody

ABP-MAB-ES002 100 ug Ask for price

Smad1/ Rat Smad1 ELISA Kit

ELA-E0647r 96 Tests
EUR 886

Smad1/ Rat Smad1 ELISA Kit

ELI-02285r 96 Tests
EUR 886

Anti-ERK1/2 (E31R) Signal Transduction Monoclonal Antibody

ABP-MAB-ES003 100 ug Ask for price

Bacillus subtilis Signal transduction histidine-protein kinase/phosphatase DegS (degS)

1-CSB-EP320275BRJ
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Bacillus subtilis Signal transduction histidine-protein kinase/phosphatase DegS(degS) expressed in E.coli

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed

ELISA-1 1
EUR 202

Sheep Smad1 ELISA Kit

ESS0276 96Tests
EUR 521

Rat Smad1 ELISA Kit

ERS0276 96Tests
EUR 521

Rabbit Smad1 ELISA Kit

ERTS0276 96Tests
EUR 521

Monkey Smad1 ELISA Kit

EMKS0276 96Tests
EUR 521

Mouse Smad1 ELISA Kit

EMS0276 96Tests
EUR 521

Porcine Smad1 ELISA Kit

EPS0276 96Tests
EUR 521

Goat Smad1 ELISA Kit

EGTS0276 96Tests
EUR 521

Bovine Smad1 ELISA Kit

EBS0276 96Tests
EUR 521

Chicken Smad1 ELISA Kit

ECKS0276 96Tests
EUR 521

Canine Smad1 ELISA Kit

ECS0276 96Tests
EUR 521

Anserini Smad1 ELISA Kit

EAS0276 96Tests
EUR 521

Smad1 Cell ELISA Kit

abx595549-96tests 96 tests
EUR 637

Human SMAD1 ELISA Kit

ELA-E0647h 96 Tests
EUR 824

Bovine SMAD1 ELISA KIT

ELI-02283b 96 Tests
EUR 928

ELISA kit for Human Signal transducer CD24

EK4372 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Signal transducer CD24 in samples from serum, plasma, tissue homogenates and other biological fluids.

SMAD1

GT15219 100 ug
EUR 526

Guinea Pig Smad1 ELISA Kit

EGS0276 96Tests
EUR 521

Smad1 DNA-Binding ELISA Kit

abx596539-96tests 96 tests
EUR 723

SMAD1 ELISA Kit (Mouse) (OKCD06627)

OKCD06627 96 Wells
EUR 1001
Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 0.125ng/mL

SMAD1 ELISA Kit (Mouse) (OKEH05787)

OKEH05787 96 Wells
EUR 662
Description: Description of target: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 31.34 pg/mL

SMAD1 ELISA Kit (Rat) (OKEH07161)

OKEH07161 96 Wells
EUR 662
Description: Description of target: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). Has been shown to be also activated by TGF-beta (transforming growth factor) type I receptor kinase in rat intestinal epithelial cells (IEC 4-1). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.159 ng/mL

SMAD1 ELISA Kit (Bovine) (OKEH07443)

OKEH07443 96 Wells
EUR 1092
Description: Description of target: ;Species reactivity: Bovine;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 36pg/mL

SMAD1 ELISA Kit (Rabbit) (OKWB00419)

OKWB00419 96 Wells
EUR 572
Description: Description of target: ;Species reactivity: Rabbit;Application: ;Assay info: Assay Type: Quantitative Sandwich ELISA;Sensitivity: 0.188 ng/mL

Smad1/MADH1 ELISA KIT|Human

EF000681 96 Tests
EUR 689

Recombinant KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1)

4-RPL650Hu01
  • EUR 499.62
  • EUR 236.00
  • EUR 1598.56
  • EUR 599.52
  • EUR 1099.04
  • EUR 397.00
  • EUR 3846.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 expressed in: E.coli

Recombinant KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1)

4-RPL650Mu01
  • EUR 510.37
  • EUR 239.00
  • EUR 1638.88
  • EUR 612.96
  • EUR 1125.92
  • EUR 404.00
  • EUR 3947.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 expressed in: E.coli

KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody

20-abx128380
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

20-abx307678
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody

20-abx104762
  • EUR 467.00
  • EUR 133.00
  • EUR 1344.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

abx034990-400ul 400 ul
EUR 523

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

abx034990-80l 80 µl
EUR 286

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

20-abx007227
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

abx224066-100ug 100 ug
EUR 411

KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody

20-abx327286
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

ELISA kit for Human Smad1 (Mothers Against Decapentaplegic Homolog 1)

ELK5269 1 plate of 96 wells
EUR 372
Description: A sandwich ELISA kit for detection of Mothers Against Decapentaplegic Homolog 1 from Human,Mouse,Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human Mothers against decapentaplegic homolog 1 (SMAD1)

KTE60576-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Mothers against decapentaplegic homolog 1 (SMAD1)

KTE60576-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Mothers against decapentaplegic homolog 1 (SMAD1)

KTE60576-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Mothers against decapentaplegic homolog 1 (SMAD1)

KTE70413-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Mouse Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Mothers against decapentaplegic homolog 1 (SMAD1)

KTE70413-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Mouse Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Mothers against decapentaplegic homolog 1 (SMAD1)

KTE70413-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Mouse Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Smad1 (Mothers Against Decapentaplegic Homolog 1)

ELK7699 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Mothers Against Decapentaplegic Homolog 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Rat Mothers against decapentaplegic homolog 1 (SMAD1)

KTE100237-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Rat Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Mothers against decapentaplegic homolog 1 (SMAD1)

KTE100237-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Rat Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Mothers against decapentaplegic homolog 1 (SMAD1)

KTE100237-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Rat Mothers against decapentaplegic homolog 1 (SMAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN320A-KIT 1 Kit
EUR 4941

ViraDuctin Retrovirus Transduction Kit (40 Transductions)

RV-200 40 transductions
EUR 363
Description: The efficiency of retrovirus infection of target cells tends to be lower than that of adenovirus. Additives such as Polybrene® can increase transduction efficiencies, but even then only a small fraction of retroviral vectors can trasduce many target cell lines. Our ViraDuctin Retrovirus Transduction Kit provides superior transduction efficiencies in a variety of cell lines, even when compared to transductions in the presence of Polybrene®. This system is ideal for many primary cells as well as immobilized cells.

ViraDuctin Retrovirus Transduction Kit (200 Transductions)

RV-201 200 transductions
EUR 780
Description: The efficiency of retrovirus infection of target cells tends to be lower than that of adenovirus. Additives such as Polybrene® can increase transduction efficiencies, but even then only a small fraction of retroviral vectors can trasduce many target cell lines. Our ViraDuctin Retrovirus Transduction Kit provides superior transduction efficiencies in a variety of cell lines, even when compared to transductions in the presence of Polybrene®. This system is ideal for many primary cells as well as immobilized cells.

ViraDuctin Lentivirus Transduction Kit (40 Transductions)

LTV-200 40 transductions
EUR 345
Description: Lentiviral expression has many advantages over other viruses, including the ability to infect both proliferating and non-proliferating cells. The efficiency of lentivirus infection of target cells, however, tends to be lower. Additives such as Polybrene can increase transduction efficiencies, but even then only a small fraction of lentiviral vectors can trasduce many target cell lines. Our ViraDuctin Lentivirus Transduction Kit provides superior lentiviral transduction efficiencies in a variety of cell lines, even when compared to transductions in the presence of Polybrene. This system is ideal for many primary cells as well as immobilized cells.

ViraDuctin Lentivirus Transduction Kit (200 Transductions)

LTV-201 200 transductions
EUR 751
Description: Lentiviral expression has many advantages over other viruses, including the ability to infect both proliferating and non-proliferating cells. The efficiency of lentivirus infection of target cells, however, tends to be lower. Additives such as Polybrene can increase transduction efficiencies, but even then only a small fraction of lentiviral vectors can trasduce many target cell lines. Our ViraDuctin Lentivirus Transduction Kit provides superior lentiviral transduction efficiencies in a variety of cell lines, even when compared to transductions in the presence of Polybrene. This system is ideal for many primary cells as well as immobilized cells.

ViraDuctin AAV Transduction Kit (10 Transductions)

AAV-200 10 transductions
EUR 421
Description: The process by which adeno-associated virus (AAV) infects host cells includes viral binding and entry, intracellular trafficking, nuclear transport, and viral second strand DNA synthesis. The second strand DNA synthesis has been shown to be the rate limiting step, which leads to inefficient transduction by AAV vectors. ViraDuctin AAV Transduction Kit is a proprietary, multi-reagent formulation designed to increase the efficiency of transduction by AAV vectors. Reagent preparation takes only 10 minutes prior to host cell infection.

ViraDuctin AAV Transduction Kit (50 Transductions)

AAV-201 50 transductions
EUR 972
Description: The process by which adeno-associated virus (AAV) infects host cells includes viral binding and entry, intracellular trafficking, nuclear transport, and viral second strand DNA synthesis. The second strand DNA synthesis has been shown to be the rate limiting step, which leads to inefficient transduction by AAV vectors. ViraDuctin AAV Transduction Kit is a proprietary, multi-reagent formulation designed to increase the efficiency of transduction by AAV vectors. Reagent preparation takes only 10 minutes prior to host cell infection.

ViraDuctin Adenovirus Transduction Kit (10 Transductions)

AD-200 10 transductions
EUR 415
Description: Adenoviral infection of most cells is mediated largely by the coxsackievirus-adenovirus receptor (CAR). In many cells, however, this receptor is either absent or present at extremely low levels, reducing the efficiency of adenovirus uptake. ViraDuctin Adenovirus Transduction Reagent is designed specifically to increase the efficiency of adenoviral transduction without regard to the level of CAR expression on the surface of the target cells.

ViraDuctin Adenovirus Transduction Kit (50 Transductions)

AD-201 50 transductions
EUR 949
Description: Adenoviral infection of most cells is mediated largely by the coxsackievirus-adenovirus receptor (CAR). In many cells, however, this receptor is either absent or present at extremely low levels, reducing the efficiency of adenovirus uptake. ViraDuctin Adenovirus Transduction Reagent is designed specifically to increase the efficiency of adenoviral transduction without regard to the level of CAR expression on the surface of the target cells.

PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)

PIN340iPS-KIT 1 Kit
EUR 4941

Mouse KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Protein

20-abx067639
  • EUR 718.00
  • EUR 286.00
  • EUR 2207.00
  • EUR 843.00
  • EUR 509.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Protein

20-abx166241
  • EUR 704.00
  • EUR 286.00
  • EUR 2151.00
  • EUR 829.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Smad1 Colorimetric Cell-Based ELISA Kit

EKC1526 100ul
EUR 572

Smad1 (pS187) DNA Binding ELISA Kit

abx596638-96tests 96 tests
EUR 754

Smad1 / 5 / 9 Cell ELISA Kit

abx595866-96tests 96 tests
EUR 637

Smad1 DNA-Binding ELISA Kit (OKAG00440)

OKAG00440 96 Wells
EUR 753
Description: Description of target: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.;Species reactivity: Human, Mouse, Rat;Application: ELISA;Assay info: Assay Type: Qualitative DNA Binding ELISA ;Sensitivity:

ELISA kit for Mouse Smad1/MADH1 (Mothers Against Decapentaplegic Homolog 1)

E-EL-M1062 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse Smad1/MADH1 (Mothers Against Decapentaplegic Homolog 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human Smad1/MADH1 (Mothers Against Decapentaplegic Homolog 1)

E-EL-H0932 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human Smad1/MADH1 (Mothers Against Decapentaplegic Homolog 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat Smad1/MADH1 (Mothers Against Decapentaplegic Homolog 1)

E-EL-R0637 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Rat Smad1/MADH1 (Mothers Against Decapentaplegic Homolog 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human SRP9 (Signal Recognition Particle 9kDa)

E-EL-H2127 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human SRP9 (Signal Recognition Particle 9kDa) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse SRP9 (Signal Recognition Particle 9kDa)

E-EL-M1054 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse SRP9 (Signal Recognition Particle 9kDa) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human SIRPa (Signal Regulatory Protein Alpha)

ELK4552 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Signal Regulatory Protein Alpha from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

The making of a protein relies on the mixture of 20 totally different monomers (22 contemplating selenocysteine and pyrrolysine, the most recent current solely in some archaea and micro organism) giving the potential of constructing a wide range of constructions from the only to essentially the most complicated, inflexible or extremely dynamic, and suited to hold out a variety of structural and practical roles On this regard, the therapeutic advantages of Wnt inhibitors use had been highlighted, thus demonstrating that Wnt/β-catenin pathway is likely to be thought-about as a therapeutic goal to stop adversarial LV transforming and coronary heart failure following MI.

Specific Features of Intracellular Signal Transduction in the Regulation of Functions of Neural Stem Cells and Committed Neuronal Progenitors

Specific Features of Intracellular Signal Transduction in the Regulation of Functions of Neural Stem Cells and Committed Neuronal Progenitors

We studied the function of NF-κB-, cAMP/PKA-, JAKs/STAT3-, ERK1/2-, p38-, JNK- and p53- mediated signaling pathways within the realization of the expansion potential of neural stem cells and dedicated neuronal progenitors beneath in vitro situations. The tactic of pharmacological blockade with selective inhibitors of particular person signaling molecules revealed some principal variations of their function within the dedication of the proliferation and differentiation standing of progenitor cells of various lessons.

Evaluation of the peculiarities of intracellular signaling in cells and comparability of the function of its particular person components attest to the prospects of growing new medication with neuroregenerative exercise based mostly on STAT3 inhibitors or JNK activators. These modulations of exercise of signaling molecules can stimulate the conclusion of the expansion potential of dedicated neuronal progenitors and impartial stem cells, respectively. The blockade of STAT3 and a rise within the content material of phosphorylated types of JNK had no “detrimental” results on the functioning of multipotent neural stem cells and dedicated neuronal progenitors, respectively.

Porphyromonas gingivalis (P. gingivalis), a Gram-negative oral anaerobe, is taken into account to be a serious pathogenic agent concerned within the onset and development of persistent periodontitis. P. gingivalis should be capable of understand and reply to the sophisticated modifications in host to outlive the environmental challenges, through which the two-component sign transduction techniques (TCSs) play essential roles by connecting enter indicators to mobile physiological output. Canonical TCS consists of a sensor histidine kinase and a cognate response regulator that features through a phosphorylation cascade.

cAMP-regulated phosphoproteins DARPP-32, ARPP16/19, and RCS modulate striatal sign transduction via protein kinases and phosphatases

Many years of analysis led by Paul Greengard recognized protein phosphorylation as a ubiquitous and very important post-translational modification concerned in lots of neuronal signaling pathways. Specifically, his discovery that second messenger-regulated protein phosphorylation performs a central function within the propagation and transduction of indicators within the nervous system has been important in understanding the molecular mechanisms of neuronal communication. The institution of dopamine (DA) as a necessary neurotransmitter within the central nervous system, mixed with observations that DA prompts G-protein-coupled receptors to manage the manufacturing of cyclic adenosine monophosphate (cAMP) in postsynaptic neurons, has supplied elementary perception into the regulation of neurotransmission.

Notably, DA signaling within the striatum is concerned in lots of neurological features corresponding to management of locomotion, reward, habit, and studying, amongst others. This evaluation focuses on the historical past, characterization, and performance of cAMP-mediated regulation of serine/threonine protein phosphatases and their function in DA-mediated signaling in striatal neurons. A number of small, heat- and acid-stable proteins, together with DARPP-32, RCS, and ARPP-16/19, had been found by the Greengard laboratory to be regulated by DA- and cAMP signaling, and located to endure a posh however coordinated sequence of phosphorylation and dephosphorylation occasions.

These research have contributed considerably to the institution of protein phosphorylation as a ubiquitous and very important course of in sign propagation in neurons, paradigm shifting discoveries on the time. Understanding DA-mediated signaling within the context of sign propagation has led to quite a few insights into human situations and the event of therapies and therapies. Importantly, many research have discovered that mineral vitamin, corresponding to N, P, and Fe, not solely impacts fruit high quality straight but in addition influences the absorption and the content material of different nutrient components.

On this evaluation, we offer insights of the mineral vitamins into their operate, transport, sign transduction related to Rosaceae fruit high quality, and postharvest storage at physiological and molecular ranges. These research will contribute to offer theoretical foundation to enhance fertilizer environment friendly utilization and fruit trade sustainable growth. On this evaluation, the roles of TCSs in P. gingivalis had been demonstrated by illustrating the goal genes and modulation modes, which can assist elucidate the underlying mechanisms in future research.

Specific Features of Intracellular Signal Transduction in the Regulation of Functions of Neural Stem Cells and Committed Neuronal Progenitors

Deciphering cell-type particular sign transduction within the mind: Challenges and guarantees

Sign transduction designates the set of molecular occasions that happen inside a cell upon extracellular stimulation to mediate a useful final result. Many years after the invention that dopamine triggers opposing signaling pathways in D1- and D2-expressing medium spiny neurons, it’s now clear that there are as many alternative flavors of signaling pathways within the mind as there are neuron varieties. One of many largest challenges in molecular neuroscience is to elucidate cell-type particular signaling, so as to perceive neurological ailments with regional vulnerability, but in addition to establish targets for precision medication devoid of off-target results. Right here, we make a case for the significance of the research of neuron-type particular molecular traits.

We then evaluation the applied sciences that exist to check neurons of their full range and spotlight their disease-relevant idiosyncrasies. Mineral vitamin, taken up from the soil or foliar sprayed, performs elementary roles in plant development and growth. Amongst of no less than 14 mineral components, the macronutrients nitrogen (N), potassium (Okay), phosphorus (P), and calcium (Ca) and the micronutrient iron (Fe) are important to Rosaceae fruit yield and high quality. Deficiencies in minerals strongly have an effect on metabolism with subsequent impacts on the expansion and growth of fruit bushes.

Human signal transduction-Smad7 ELISA Kit

CN-03385H1 96T
EUR 448

Human signal transduction-Smad7 ELISA Kit

CN-03385H2 48T
EUR 297

Rat signal transduction-Smad1 ELISA Kit

CN-01425R1 96T
EUR 439

Rat signal transduction-Smad1 ELISA Kit

CN-01425R2 48T
EUR 290

Rat signal transduction-Smad7 ELISA Kit

CN-01426R1 96T
EUR 442

Rat signal transduction-Smad7 ELISA Kit

CN-01426R2 48T
EUR 293

PLATEMAX ULTRA CLEAR PERMANENT HEAT SEALING FILM FOR QPCR, 100/500

HS-100-QPCR 100/pk
EUR 318
Description: Sealing Products; Sealing films - Axygen

PLATEMAX ULTRA CLEAR PEELABLE HEAT SEALING FILM FOR QPCR. 100/500

HS-150-QPCR 100/pk
EUR 318
Description: Sealing Products; Sealing films - Axygen

LncRNA Profiler Complete qPCR Array Kit (cDNA synthesis kit, qPCR array and SYBR Green reagent) 20 profiles

RA910A-1 20 profiles
EUR 1108

Anti-ERK1 (E32) Signal Transduction Monoclonal Antibody

ABP-MAB-ES001 100 ug Ask for price

Anti-ERK1 (E19) Signal Transduction Monoclonal Antibody

ABP-MAB-ES002 100 ug Ask for price

Anti-ERK1/2 (E31R) Signal Transduction Monoclonal Antibody

ABP-MAB-ES003 100 ug Ask for price

Human Signal transduction protein CBL- C, CBLC ELISA KIT

ELI-50273h 96 Tests
EUR 824

Mouse Signal transduction protein CBL- C, Cblc ELISA KIT

ELI-33118m 96 Tests
EUR 865

Bacillus subtilis Signal transduction histidine-protein kinase/phosphatase DegS (degS)

1-CSB-EP320275BRJ
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Bacillus subtilis Signal transduction histidine-protein kinase/phosphatase DegS(degS) expressed in E.coli

QuantiSir Specific Gene Knockdown Quantification Kit For Signal Transduction - ViDR

P-5008 96 Assays
EUR 788.05
Description: Ask the seller for details

Recombinant KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1)

4-RPL650Hu01
  • EUR 499.62
  • EUR 236.00
  • EUR 1598.56
  • EUR 599.52
  • EUR 1099.04
  • EUR 397.00
  • EUR 3846.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 expressed in: E.coli

Recombinant KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1)

4-RPL650Mu01
  • EUR 510.37
  • EUR 239.00
  • EUR 1638.88
  • EUR 612.96
  • EUR 1125.92
  • EUR 404.00
  • EUR 3947.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 expressed in: E.coli

KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody

20-abx128380
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

20-abx307678
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody

20-abx104762
  • EUR 467.00
  • EUR 133.00
  • EUR 1344.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

abx034990-400ul 400 ul
EUR 523

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

abx034990-80l 80 µl
EUR 286

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

20-abx007227
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 2 (KHDRBS2) Antibody

abx224066-100ug 100 ug
EUR 411

KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Antibody

20-abx327286
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Nylon Array

MVSNGA110 10 Slides
EUR 226

Nylon Array

MVSNGA120 20 Slides
EUR 363

Array Designer

AD6 1
EUR 4248

Mouse KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Protein

20-abx067639
  • EUR 718.00
  • EUR 286.00
  • EUR 2207.00
  • EUR 843.00
  • EUR 509.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human KH Domain Containing, RNA Binding, Signal Transduction Associated Protein 1 (KHDRBS1) Protein

20-abx166241
  • EUR 704.00
  • EUR 286.00
  • EUR 2151.00
  • EUR 829.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Universal qPCR Mixture

QPCR1000-UNIV