The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application

The Wnt/β signaling pathway (Wnt-SP) is a phylogenetically ancient mechanism that regulates development and maintains tissue homeostasis through the control of cell proliferation, differentiation, migration, and apoptosis.

The accurate regulation of the canonical Wnt/β-catenin signaling pathway (Wnt-SP) is critical for embryogenesis and postnatal development; and impaired signaltransduction at one of its stages leads to various diseases, including organ malformations, cancers, metabolic and neurodegenerative disorders. The literature review discusses the biological role of the canonical Wnt-SP in the development of the skeleton and in the remodeling of bone tissue.

The Wnt signal transmission changes observed during genetic mutations cause various human skeletal diseases.

CKMM protein
30-AC60	Fitzgerald	1 mg	EUR 400
Description: Purified native Human CKMM protein

CKMM protein
30-AC61	Fitzgerald	100 ug	EUR 1428
Description: Purified recombinant CKMM protein

CKMM protein
30R-3024	Fitzgerald	200 ug	EUR 424.8
Description: Purified recombinant CKMM protein

CKMM protein
MBS5304001-1mg	MyBiosource	1mg	EUR 1030

CKMM protein
MBS5304001-5x1mg	MyBiosource	5x1mg	EUR 4420

CKMM protein
MBS537486-1mg	MyBiosource	1mg	EUR 535

CKMM protein
MBS537486-5x1mg	MyBiosource	5x1mg	EUR 2260

CKMM protein
MBS538232-05mg	MyBiosource	0.5mg	EUR 1780

CKMM protein
MBS538232-5x05mg	MyBiosource	5x0.5mg	EUR 7800

CKMM antibody
10-C41A	Fitzgerald	1 mg	EUR 471
Description: Mouse monoclonal CKMM antibody

CKMM antibody
10-C41B	Fitzgerald	1 mg	EUR 384
Description: Mouse monoclonal CKMM antibody

CKMM antibody
10R-8516	Fitzgerald	100 ul	EUR 471.6
Description: Mouse monoclonal CKMM antibody

CKMM antibody
10C-CR3014M1	Fitzgerald	1 mg	EUR 471
Description: Mouse monoclonal CKMM antibody

CKMM antibody
10C-CR3014M2	Fitzgerald	1 mg	EUR 384
Description: Mouse monoclonal CKMM antibody

CKMM antibody
10C-CR3014M3	Fitzgerald	1 mg	EUR 512
Description: Mouse monoclonal CKMM antibody

CKMM antibody
20-CG75	Fitzgerald	1 ml	EUR 132
Description: Goat polyclonal CKMM antibody

CKMM antibody
20-CR75	Fitzgerald	1 ml	EUR 132
Description: Rabbit polyclonal CKMM antibody

CKMM antibody
20R-CK004	Fitzgerald	1 L	Ask for price
Description: Goat polyclonal CKMM antiserum

CKMM antibody
20C-CR3014G	Fitzgerald	1 ml	EUR 144
Description: Goat polyclonal CKMM antibody

CKMM antibody
70R-15270	Fitzgerald	100 ug	EUR 302
Description: Rabbit polyclonal CKMM antibody

CKMM antibody
70R-1984	Fitzgerald	50 ug	EUR 467
Description: Rabbit polyclonal CKMM antibody raised against the N terminal of CKM

CKMM antibody
70R-1985	Fitzgerald	50 ug	EUR 467
Description: Rabbit polyclonal CKMM antibody raised against the middle region of CKM

CKMM antibody
70R-33149	Fitzgerald	100 ug	EUR 451
Description: Rabbit polyclonal CKMM antibody

CKMM antibody
70-XG47	Fitzgerald	1 mg	EUR 314
Description: Affinity purified Goat polyclonal CKMM antibody

CKMM antibody
70R-CG004	Fitzgerald	1 G	Ask for price
Description: Affinity purified Goat polyclonal CKMM antibody

CKMM antibody
MBS838744-INQUIRE	MyBiosource	INQUIRE	Ask for price

CKMM antibody
MBS839099-01mL	MyBiosource	0.1mL	EUR 750

CKMM antibody
MBS839099-5x01mL	MyBiosource	5x0.1mL	EUR 3215

CKMM antibody
MBS5300612-01mL	MyBiosource	0.1mL	EUR 670

CKMM antibody
MBS5300612-5x01mL	MyBiosource	5x0.1mL	EUR 2875

CKMM antibody
MBS531826-1mg	MyBiosource	1mg	EUR 735

CKMM antibody
MBS531826-5x1mg	MyBiosource	5x1mg	EUR 3155

CKMM antibody
MBS5302966-01mg	MyBiosource	0.1mg	EUR 510

CKMM antibody
MBS5302966-5x01mg	MyBiosource	5x0.1mg	EUR 2150

CKMM antibody
MBS5303280-01mL	MyBiosource	0.1mL	EUR 750

CKMM antibody
MBS5303280-5x01mL	MyBiosource	5x0.1mL	EUR 3215

CKMM antibody
MBS530452-1mg	MyBiosource	1mg	EUR 835

CKMM antibody
MBS530452-5x1mg	MyBiosource	5x1mg	EUR 3600

CKMM antibody
MBS531070-1mg	MyBiosource	1mg	EUR 835

CKMM antibody
MBS531070-5x1mg	MyBiosource	5x1mg	EUR 3600

CKMM antibody
MBS531102-1mg	MyBiosource	1mg	EUR 705

CKMM antibody
MBS531102-5x1mg	MyBiosource	5x1mg	EUR 3015

CKMM antibody
MBS534823-1mL	MyBiosource	1mL	EUR 240

CKMM antibody
MBS534823-5x1mL	MyBiosource	5x1mL	EUR 925

CKMM antibody
MBS534876-INQUIRE	MyBiosource	INQUIRE	Ask for price

CKMM antibody
MBS535053-1mg	MyBiosource	1mg	EUR 575

CKMM antibody
MBS535053-5x1mg	MyBiosource	5x1mg	EUR 2440

CKMM antibody
MBS535367-1mL	MyBiosource	1mL	EUR 240

CKMM antibody
MBS535367-5x1mL	MyBiosource	5x1mL	EUR 925

CKMM antibody
MBS536263-1mL	MyBiosource	1mL	EUR 290

CKMM antibody
MBS536263-5x1mL	MyBiosource	5x1mL	EUR 1155

CKMM antibody
MBS531406-1mg	MyBiosource	1mg	EUR 705

CKMM antibody
MBS531406-5x1mg	MyBiosource	5x1mg	EUR 3015

CKMM antibody (HRP)
60R-1648	Fitzgerald	100 ug	EUR 302
Description: Rabbit polyclonal CKMM antibody (HRP)

Rat CKMM Antibody
32939-05111	AssayPro	150 ug	EUR 215

CKMM antibody (HRP)
MBS839368-01mg	MyBiosource	0.1mg	EUR 510

CKMM antibody (HRP)
MBS839368-5x01mg	MyBiosource	5x0.1mg	EUR 2150

CKMM antibody (FITC)
60R-1649	Fitzgerald	100 ug	EUR 302
Description: Rabbit polyclonal CKMM antibody (FITC)

CKMM antibody (FITC)
MBS5301444-01mg	MyBiosource	0.1mg	EUR 510

CKMM antibody (FITC)
MBS5301444-5x01mg	MyBiosource	5x0.1mg	EUR 2150

Mouse CKMM Antibody
32938-05111	AssayPro	150 ug	EUR 215

CKMM antibody (biotin)
60R-1650	Fitzgerald	100 ug	EUR 305
Description: Rabbit polyclonal CKMM antibody (biotin)

CKMM antibody (biotin)
MBS5300197-01mg	MyBiosource	0.1mg	EUR 515

CKMM antibody (biotin)
MBS5300197-5x01mg	MyBiosource	5x0.1mg	EUR 2170

CKMM Blocking Peptide
33R-3630	Fitzgerald	100 ug	EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1985

CKMM Blocking Peptide
33R-9549	Fitzgerald	100 ug	EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1984

CKMM Type 1 protein
30R-AC026	Fitzgerald	1 mg	EUR 898
Description: Purified recombinant CKMM Type 1 protein

CKMM Type 1 protein
MBS538270-1mg	MyBiosource	1mg	EUR 1450

CKMM Type 1 protein
MBS538270-5x1mg	MyBiosource	5x1mg	EUR 6305

Human ckmm PicoKine ELISA Kit
EK1751	BosterBio	96 wells	EUR 510
Description: For quantitative detection of human ckmm in cell culture supernates, serum and plasma (heparin, EDTA).

CKMM | creatine kinase M-type
AS10-1318	Agrisera AB	1 mg	EUR 243

Human ckmm PicoKine ELISA Kit
MBS1751625-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2755

Human ckmm PicoKine ELISA Kit
MBS1751625-96StripWells	MyBiosource	96-Strip-Wells	EUR 600

Rat CKMM Antibody (Biotin Conjugate)
32939-05121	AssayPro	150 ug	EUR 315

Mouse CKMM Antibody (Biotin Conjugate)
32938-05121	AssayPro	150 ug	EUR 315

Creatine Kinase MM Isoenzyme (CKMM) (AP)
MBS6126122-01mL	MyBiosource	0.1(mL	EUR 920

Creatine Kinase MM Isoenzyme (CKMM) (AP)
MBS6126122-5x01mL	MyBiosource	5x0.1mL	EUR 3980

Creatine Kinase MM Isoenzyme (CKMM) (AP)
MBS6126123-01mL	MyBiosource	0.1(mL	EUR 830

Creatine Kinase MM Isoenzyme (CKMM) (AP)
MBS6126123-5x01mL	MyBiosource	5x0.1mL	EUR 3590

Creatine Kinase MM Isoenzyme (CKMM) (PE)
MBS6129216-01mL	MyBiosource	0.1(mL	EUR 920

Creatine Kinase MM Isoenzyme (CKMM) (PE)
MBS6129216-5x01mL	MyBiosource	5x0.1mL	EUR 3980

Creatine Kinase MM Isoenzyme (CKMM) (PE)
MBS6129217-01mL	MyBiosource	0.1(mL	EUR 830

Creatine Kinase MM Isoenzyme (CKMM) (PE)
MBS6129217-5x01mL	MyBiosource	5x0.1mL	EUR 3590

Creatine Kinase MM Isoenzyme (CKMM) (AP)
MBS6260144-01mL	MyBiosource	0.1mL	EUR 1395

Creatine Kinase MM Isoenzyme (CKMM) (AP)
MBS6260144-5x01mL	MyBiosource	5x0.1mL	EUR 6125

Creatine Kinase MM Isoenzyme (CKMM) (PE)
MBS6262695-01mL	MyBiosource	0.1mL	EUR 1395

Creatine Kinase MM Isoenzyme (CKMM) (PE)
MBS6262695-5x01mL	MyBiosource	5x0.1mL	EUR 6125

CKMM | Human Creatine Kinase, M subunit
AS16-3265	Agrisera AB	1 ml	EUR 144

Creatine Kinase MM Isoenzyme (CKMM) (HRP)
MBS6128595-01mL	MyBiosource	0.1(mL	EUR 920

Creatine Kinase MM Isoenzyme (CKMM) (HRP)
MBS6128595-5x01mL	MyBiosource	5x0.1mL	EUR 3980

Creatine Kinase MM Isoenzyme (CKMM) (HRP)
MBS6128596-01mL	MyBiosource	0.1(mL	EUR 830

Creatine Kinase MM Isoenzyme (CKMM) (HRP)
MBS6128596-5x01mL	MyBiosource	5x0.1mL	EUR 3590

Creatine Kinase MM Isoenzyme (CKMM) (APC)
MBS6126740-01mL	MyBiosource	0.1(mL	EUR 920

Creatine Kinase MM Isoenzyme (CKMM) (APC)
MBS6126740-5x01mL	MyBiosource	5x0.1mL	EUR 3980

Creatine Kinase MM Isoenzyme (CKMM) (APC)
MBS6126741-01mL	MyBiosource	0.1(mL	EUR 830

Creatine Kinase MM Isoenzyme (CKMM) (APC)
MBS6126741-5x01mL	MyBiosource	5x0.1mL	EUR 3590

Creatine Kinase MM Isoenzyme (CKMM) (HRP)
MBS6262185-01mL	MyBiosource	0.1mL	EUR 1395

Creatine Kinase MM Isoenzyme (CKMM) (HRP)
MBS6262185-5x01mL	MyBiosource	5x0.1mL	EUR 6125

Creatine Kinase MM Isoenzyme (CKMM) (APC)
MBS6260655-01mL	MyBiosource	0.1mL	EUR 1395

Creatine Kinase MM Isoenzyme (CKMM) (APC)
MBS6260655-5x01mL	MyBiosource	5x0.1mL	EUR 6125

Highly pure native Human CKMM protein
MBS5308288-100Units	MyBiosource	100Units	EUR 555

Highly pure native Human CKMM protein
MBS5308288-5x100Units	MyBiosource	5x100Units	EUR 2335

Creatine Kinase MM Isoenzyme (CKMM) (FITC)
MBS6127979-01mL	MyBiosource	0.1(mL	EUR 920

Creatine Kinase MM Isoenzyme (CKMM) (FITC)
MBS6127979-5x01mL	MyBiosource	5x0.1mL	EUR 3980

Creatine Kinase MM Isoenzyme (CKMM) (FITC)
MBS6127980-01mL	MyBiosource	0.1(mL	EUR 830

Creatine Kinase MM Isoenzyme (CKMM) (FITC)
MBS6127980-5x01mL	MyBiosource	5x0.1mL	EUR 3590

Creatine Kinase MM Isoenzyme (CKMM) (FITC)
MBS6261675-01mL	MyBiosource	0.1mL	EUR 1395

Creatine Kinase MM Isoenzyme (CKMM) (FITC)
MBS6261675-5x01mL	MyBiosource	5x0.1mL	EUR 6125

Recombinant Human CKMM protein (C-6His)
CD02031-10ug	Jiaxing Korain Biotech Ltd (BT Labs)	10ug	EUR 202
Description: Recombinant Human Creatine Kinase, Muscle is produced by our Mammalian expression system and the target gene encoding Met1-Lys381 is expressed with a 6His tag at the C-terminus.

Recombinant Human CKMM protein (C-6His)
CD02031-50ug	Jiaxing Korain Biotech Ltd (BT Labs)	50ug	EUR 470
Description: Recombinant Human Creatine Kinase, Muscle is produced by our Mammalian expression system and the target gene encoding Met1-Lys381 is expressed with a 6His tag at the C-terminus.

Creatine Kinase MM Isoenzyme, Human, (CKMM)
MBS653871-02mg	MyBiosource	0.2mg	EUR 525

Creatine Kinase MM Isoenzyme, Human, (CKMM)
MBS653871-1mg	MyBiosource	1mg	EUR 1000

Creatine Kinase MM Isoenzyme, Human, (CKMM)
MBS653871-5x1mg	MyBiosource	5x1mg	EUR 4345

Creatine Kinase MM Isoenzyme (CKMM) (Biotin)
MBS6127360-01mL	MyBiosource	0.1(mL	EUR 920

Creatine Kinase MM Isoenzyme (CKMM) (Biotin)
MBS6127360-5x01mL	MyBiosource	5x0.1mL	EUR 3980

Creatine Kinase MM Isoenzyme (CKMM) (Biotin)
MBS6127361-01mL	MyBiosource	0.1(mL	EUR 830

Creatine Kinase MM Isoenzyme (CKMM) (Biotin)
MBS6127361-5x01mL	MyBiosource	5x0.1mL	EUR 3590

Creatine Kinase MM Isoenzyme (CKMM) (Biotin)
MBS6261166-01mL	MyBiosource	0.1mL	EUR 1395

Creatine Kinase MM Isoenzyme (CKMM) (Biotin)
MBS6261166-5x01mL	MyBiosource	5x0.1mL	EUR 6125

Recombinant Human CKMM/CKM Protein, His Tag
E40KMH880	EnoGene	20ug	EUR 495

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (PE)
MBS6186831-01mL	MyBiosource	0.1(mL	EUR 875

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (PE)
MBS6186831-5x01mL	MyBiosource	5x0.1mL	EUR 3800

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (PE)
MBS6184023-01mL	MyBiosource	0.1(mL	EUR 875

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (PE)
MBS6184023-5x01mL	MyBiosource	5x0.1mL	EUR 3800

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (AP)
MBS6161973-01mL	MyBiosource	0.1(mL	EUR 875

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (AP)
MBS6161973-5x01mL	MyBiosource	5x0.1mL	EUR 3800

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (AP)
MBS6164781-01mL	MyBiosource	0.1(mL	EUR 875

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (AP)
MBS6164781-5x01mL	MyBiosource	5x0.1mL	EUR 3800

Human Creatine Kinase, Muscle(CKMM) Elisa Kit
EK700626	AFG Bioscience LLC	96 Wells	EUR 0.5

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (HRP)
MBS6182421-01mL	MyBiosource	0.1(mL	EUR 875

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (HRP)
MBS6182421-5x01mL	MyBiosource	5x0.1mL	EUR 3800

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (APC)
MBS6169191-01mL	MyBiosource	0.1(mL	EUR 875

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (APC)
MBS6169191-5x01mL	MyBiosource	5x0.1mL	EUR 3800

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (APC)
MBS6166383-01mL	MyBiosource	0.1(mL	EUR 875

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (APC)
MBS6166383-5x01mL	MyBiosource	5x0.1mL	EUR 3800

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (HRP)
MBS6179613-01mL	MyBiosource	0.1(mL	EUR 875

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (HRP)
MBS6179613-5x01mL	MyBiosource	5x0.1mL	EUR 3800

Human Creatine Kinase M-type (CKMM) Antibody
11281-05011	AssayPro	150 ug	EUR 175

Rat CKMM AssayLite™ Antibody (APC Conjugate)
32939-05161	AssayPro	150 ug	EUR 370

CKM (Creatine Kinase, Muscle, CKMM, M-CK) (FITC)
MBS6178011-01mL	MyBiosource	0.1(mL	EUR 875

Understanding the functional mechanism involved in the development of bone abnormality could open new horizons in the treatment of osteoporosis, by affecting the Wnt-SP. The design of antibodies to sclerostin, a Wnt-SP inhibitor, is most promising now. The paper summarizes the studies that have investigated the canonical Wnt-SP and designed drugs to treat osteoporosis.