The canonical Wnt/β-catenin pathway: From the history of its discovery to clinical application

The Wnt/β signaling pathway (Wnt-SP) is a phylogenetically ancient mechanism that regulates development and maintains tissue homeostasis through the control of cell proliferation, differentiation, migration, and apoptosis.

The accurate regulation of the canonical Wnt/β-catenin signaling pathway (Wnt-SP) is critical for embryogenesis and postnatal development; and impaired signaltransduction at one of its stages leads to various diseases, including organ malformations, cancers, metabolic and neurodegenerative disorders. The literature review discusses the biological role of the canonical Wnt-SP in the development of the skeleton and in the remodeling of bone tissue.

The Wnt signal transmission changes observed during genetic mutations cause various human skeletal diseases.

CKMM protein

30-1084U 100 units
EUR 279
Description: Highly pure native Human CKMM protein

CKMM protein

30-1369 500 ug
EUR 392
Description: Recombinant CKMM protein

CKMM protein

30-AC60 1 mg
EUR 398
Description: Purified native Human CKMM protein

CKMM protein

30-AC61 100 ug
EUR 271
Description: Purified recombinant CKMM protein

CKMM antibody

20C-CR3014G 1 ml
EUR 225
Description: Goat polyclonal CKMM antibody

CKMM antibody

70R-1984 50 ug
EUR 467
Description: Rabbit polyclonal CKMM antibody raised against the N terminal of CKM

CKMM antibody

70R-1985 50 ug
EUR 467
Description: Rabbit polyclonal CKMM antibody raised against the middle region of CKM

CKMM antibody

70-XG47 1 mg
EUR 324
Description: Affinity purified Goat polyclonal CKMM antibody

CKMM antibody

70R-15270 100 ug
EUR 327
Description: Rabbit polyclonal CKMM antibody

CKMM antibody

10C-CR3014M1 1 mg
EUR 495
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10C-CR3014M2 1 mg
EUR 379
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10C-CR3014M3 1 mg
EUR 495
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10-C41A 1 mg
EUR 495
Description: Mouse monoclonal CKMM antibody

CKMM antibody

10-C41B 1 mg
EUR 379
Description: Mouse monoclonal CKMM antibody

CKMM antibody

20-CG75 1 ml
EUR 173
Description: Goat polyclonal CKMM antibody

CKMM antibody

20-CR75 1 ml
EUR 173
Description: Rabbit polyclonal CKMM antibody

CKMM antibody

10R-8516 100 ul
EUR 393
Description: Mouse monoclonal CKMM antibody

CKMM antibody

70R-33149 100 ug
EUR 435
Description: Rabbit polyclonal CKMM antibody

CKMM, Human

LF-P0096 0.2 mg
EUR 303
Description: CKMM, Human protein

CKMM Blocking Peptide

33R-3630 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1985

CKMM Blocking Peptide

33R-9549 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CKM antibody, catalog no. 70R-1984

Mouse CKMM Antibody

32938-05111 150 ug
EUR 261

Rat CKMM Antibody

32939-05111 150 ug
EUR 261

CKMM antibody (HRP)

60R-1648 100 ug
EUR 327
Description: Rabbit polyclonal CKMM antibody (HRP)

CKMM antibody (FITC)

60R-1649 100 ug
EUR 327
Description: Rabbit polyclonal CKMM antibody (FITC)

CKMM antibody (biotin)

60R-1650 100 ug
EUR 349
Description: Rabbit polyclonal CKMM antibody (biotin)

anti-CKMM (3C3)

LF-MA0399 100 ul
EUR 334
Description: Mouse monoclonal to CKMM

anti-CKMM (11B11)

LF-MA0400 100 ul
EUR 334
Description: Mouse monoclonal to CKMM

7095B 9 PASTEUR PIPET

7095B-9 200/pk
EUR 70
Description: Disposable Pipets; Pasteur Pipets

Individual Reaction Mix 9

G065-9 200 reactions
EUR 167

7095D 9 PASTEUR PIPET BOROSILICATE

7095D-9 200/pk
EUR 78
Description: Disposable Pipets; Pasteur Pipets

CKMM Type 1 protein

30R-AC026 1 mg
EUR 791
Description: Purified recombinant CKMM Type 1 protein

Mouse CKMM Antibody (Biotin Conjugate)

32938-05121 150 ug
EUR 369

Rat CKMM Antibody (Biotin Conjugate)

32939-05121 150 ug
EUR 369

Human ckmm PicoKine ELISA Kit

EK1751 96 wells
EUR 425
Description: For quantitative detection of human ckmm in cell culture supernates, serum and plasma (heparin, EDTA).

Human Brain Tissue Preparation Buffer 9: Normal Nerve Microglia

9-80021 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 9: Kidney Tumor Cells

9-80032 1 x 100 ml Ask for price

Mouse Brain Tissue Preparation Buffer 9: Normal Nerve Microglia

9-80132 1 x 100 ml Ask for price

Rat Brain Tissue Preparation Buffer 9: Normal Neuron Cells

9-80227 1 x 100 ml Ask for price

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DLR-Ang1-9-Hu-48T 48T
EUR 501
  • Should the Human Angiotensin 1-9 (Ang1-9) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Angiotensin 1-9 (Ang1-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

DLR-Ang1-9-Hu-96T 96T
EUR 651
  • Should the Human Angiotensin 1-9 (Ang1-9) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Angiotensin 1-9 (Ang1-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RD-Ang1-9-Hu-48Tests 48 Tests
EUR 503

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RD-Ang1-9-Hu-96Tests 96 Tests
EUR 697

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RDR-Ang1-9-Hu-48Tests 48 Tests
EUR 525

Human Angiotensin 1-9 (Ang1-9) ELISA Kit

RDR-Ang1-9-Hu-96Tests 96 Tests
EUR 729

Mouse CKMM AssayLite Antibody (FITC Conjugate)

32938-05141 150 ug
EUR 428

Mouse CKMM AssayLite Antibody (RPE Conjugate)

32938-05151 150 ug
EUR 428

Mouse CKMM AssayLite Antibody (APC Conjugate)

32938-05161 150 ug
EUR 428

Mouse CKMM AssayLite Antibody (PerCP Conjugate)

32938-05171 150 ug
EUR 471

Rat CKMM AssayLite Antibody (FITC Conjugate)

32939-05141 150 ug
EUR 428

Rat CKMM AssayLite Antibody (RPE Coinjugate)

32939-05151 150 ug
EUR 428

Rat CKMM AssayLite Antibody (APC Conjugate)

32939-05161 150 ug
EUR 428

Rat CKMM AssayLite Antibody (PerCP Conjugate)

32939-05171 150 ug
EUR 471

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DLR-CA19-9-Hu-48T 48T
EUR 441
  • Should the Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-9 (CA19-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

DLR-CA19-9-Hu-96T 96T
EUR 570
  • Should the Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-9 (CA19-9) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RDR-CA19-9-Hu-48Tests 48 Tests
EUR 455

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RDR-CA19-9-Hu-96Tests 96 Tests
EUR 629

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RD-CA19-9-Hu-48Tests 48 Tests
EUR 436

Human Carbohydrate Antigen 19-9 (CA19-9) ELISA Kit

RD-CA19-9-Hu-96Tests 96 Tests
EUR 601

Human Creatine Kinase M-type (CKMM) Antibody

11281-05011 150 ug
EUR 217

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-10ug 10ug
EUR 141
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-1mg 1mg
EUR 1674
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-500ug 500ug
EUR 1186
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Recombinant Human Creatine Kinase, Muscle/CKMM (C-6His)

CC96-50ug 50ug
EUR 263
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5.

Human Creatine Kinase M-type (CKMM) Antibody (Biotin Conjugate)

11281-05021 150 ug
EUR 276

Mouse pre-microRNA Expression Construct mir-9-1

MMIR-9-1-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Mouse pre-microRNA Expression Construct mir-9-2

MMIR-9-2-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Mouse pre-microRNA Expression Construct mir-9-3

MMIR-9-3-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

CEA (Cancer antigen) ELISA test

9 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of CEA (Cancer antigen)

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (FITC Conjugate)

11281-05041 150 ug
EUR 428

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (RPE Conjugate)

11281-05051 150 ug
EUR 428

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (APC Conjugate)

11281-05061 150 ug
EUR 428

Human Creatine Kinase M-type (CKMM) AssayLite Antibody (PerCP Conjugate)

11281-05071 150 ug
EUR 471

AQP1-AQP9 and AQPAP control/blocking peptides (25 ug each of AQP1-9)

AQP0-9-AP-P 25 ug x10
EUR 986

Rabbit Anti-AQP1-AQP9 and AQPAP Antiserum (25 ul each of AQP1-9)

AQP0-9-AP-S 25 ul x10
EUR 1085

Rabbit Anti-AQP1-AQP9 and AQPAP, aff. pure (25 ug each of AQP1-9)

AQP0-9-AP-A 25 ul x10
EUR 1207

Frizzled 9 (Frizzled 9) Antibody

20-abx008534
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Calpain 9 (Calpain 9) Antibody

20-abx111332
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Frizzled 9 (Frizzled 9) Antibody

20-abx121993
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Frizzled 9 (Frizzled 9) Antibody

abx233223-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Calpain 9 (Calpain 9) Antibody

abx231218-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Matrix Metalloproteinase 9 (MMP-9)

GT15020 100 ug
EUR 526

IL-9, Interleukin-9, human

RC212-20 10ug
EUR 169.63
  • Product category: Proteins/Recombinant Proteins/Cytokines

Human Keratin- associated protein 9- 9, KRTAP9-9 ELISA KIT

ELI-38944h 96 Tests
EUR 824

Human Interleukin-9 (IL-9) Antibody

32578-05111 150 ug
EUR 261

Mouse Galectin-9 (Gal-9) Antibody

32253-05111 150 ug
EUR 261

Angiotensin 1-9 (Ang1-9) Antibody

20-abx132109
  • EUR 342.00
  • EUR 885.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Matrix Metalloproteinase 9 (MMP-9) Antibody

abx414532-02mg 0.2 mg
EUR 634
  • Shipped within 1 week.

Matrix Metalloproteinase 9 (MMP-9) Antibody

abx414533-01mg 0.1 mg
EUR 439
  • Shipped within 1 week.

Human 19-9(CA19-9)ELISA

QY-E05335 96T
EUR 374

Rat Angiotensin 1-9(Ang1-9)

QY-E11784 96T
EUR 374

AA26-9

B2159-5
EUR 207

ISX 9

B5596-10 10 mg
EUR 251

ISX 9

B5596-50 50 mg
EUR 902

Tyrphostin 9

B1494-25 25 mg
EUR 108
Description: Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5?M [1].Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991.

Tyrphostin 9

B1494-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5?M [1].Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991.

Tyrphostin 9

B1494-50 50 mg
EUR 119
Description: Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5?M [1].Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991.

SC-9

B6302-10 10 mg
EUR 284

Understanding the functional mechanism involved in the development of bone abnormality could open new horizons in the treatment of osteoporosis, by affecting the Wnt-SP. The design of antibodies to sclerostin, a Wnt-SP inhibitor, is most promising now. The paper summarizes the studies that have investigated the canonical Wnt-SP and designed drugs to treat osteoporosis.